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Type-selective muscular degeneration promotes infiltrative growth of intramuscular lipoma
Type-selective muscular degeneration promotes infiltrative growth of intramuscular lipoma
- Source :
- BMC Musculoskeletal Disorders, BMC Musculoskeletal Disorders, Vol 5, Iss 1, p 20 (2004)
- Publication Year :
- 2004
-
Abstract
- Background Intramuscular lipoma is a relatively common benign neoplasm that is occasionally described as an infiltrating lipoma. Typical benign tumors show a clear margin, however, the infiltrative growth pattern of this lipoma mimics that of a malignant tumor. Although its growth has an effect on muscle bundles and it is known to never metastasize, the mechanism of infiltrative growth is not well understood. Previously, little attention has been paid to pathogenic features of muscle fibers around an intramuscular lipoma. Methods In the present study, we focused on pathologic changes of the surrounding skeletal muscles especially to the degenerative features of involving muscular types, and evaluate the role of type-selective muscular degeneration for the infiltrative growth of intramuscular lipomas. Following a review of the medical records in our institute, 17 lesions containing muscle tissues in their specimens (15 infiltrating lipomas, 2 well-circumscribed lipomas) were analyzed immunohistochemically. The tumor from the most recent case was also subjected to ultrastructural analysis. Two cases of the traumatic muscle damage were also evaluated as the control experiments. Results These analyses revealed type-selective muscle involution in 11 of 17 intramuscular lipomas and in 10 of 11 of the infiltrative type, with an involving pattern that resembled that of a neurogenic or myogenic disorder. Immunoreactivity to cathepsin-D, a lysosomal catabolic enzyme, was increased in the involved muscle fibers. Subsarcolemmal vacuoles in the muscle fibers of the peripheral areas were also positive for cathepsin-D, while degenerative findings were not visually apparent in these areas. Ultrastructural analysis revealed degenerative changes in those fibers. Neither positive staining for cathepsin-D nor type-selective atrophy was detected in the sections of traumatic muscle damage. Conclusions Our findings suggest that type-selective muscular degeneration and endomysial fatty growth as a result of atrophy may modulate the infiltrating growth characteristic of intramuscular lipoma.
- Subjects :
- Adult
Male
Pathology
medicine.medical_specialty
lcsh:Diseases of the musculoskeletal system
Adolescent
Degeneration (medical)
Calcium-Transporting ATPases
Cathepsin D
Atrophy
Rheumatology
Troponin T
Infiltrative Growth Pattern
Infiltrating Lipoma
medicine
otorhinolaryngologic diseases
Adipocytes
Neoplasm
Humans
Involution (medicine)
Orthopedics and Sports Medicine
Neoplasm Invasiveness
Muscle, Skeletal
Aged
Retrospective Studies
Muscle Neoplasms
business.industry
Intramuscular Lipoma
Anatomy
Lipoma
Middle Aged
medicine.disease
Mitochondria, Muscle
stomatognathic diseases
Muscular Atrophy
Muscle Fibers, Slow-Twitch
Child, Preschool
Muscle Fibers, Fast-Twitch
Female
lcsh:RC925-935
business
Research Article
Subjects
Details
- ISSN :
- 14712474
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- BMC musculoskeletal disorders
- Accession number :
- edsair.doi.dedup.....8bd0ddb8381392acea1f2c3c0ca0d42f