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Oxidative damage of the gastric mucosa in Helicobacter pylori positive chronic atrophic and nonatrophic gastritis, before and after eradication
- Source :
- Helicobacter. 8(5)
- Publication Year :
- 2003
-
Abstract
- Background. Helicobacter pylori is the main cause of gastritis and a primary carcinogen. The aim of this study was to assess oxidative damage in mucosal compartments of gastric mucosa in H. pylori positive and negative atrophic and nonatrophic gastritis. Materials and methods. Five groups of 10 patients each were identified according to H. pylori positive or negative chronic atrophic (Hp-CAG and CAG, respectively) and nonatrophic gastritis (Hp-CG and CG, respectively), and H. pylori negative normal mucosa (controls). Oxidative damage was evaluated by nitrotyrosine immunohistochemistry in the whole mucosa and in each compartment at baseline and at 2 and 12 months after eradication. Types of intestinal metaplasia were classified by histochemistry. Results. Total nitrotyrosine levels appeared significantly higher in H. pylori positive than in negative patients, and in Hp-CAG than in Hp-CG (p
- Subjects :
- Adult
Gastritis, Atrophic
Male
medicine.medical_specialty
Pathology
Chronic gastritis
Gastroenterology
Helicobacter Infections
chemistry.chemical_compound
Metaplasia
Internal medicine
Gastric mucosa
Medicine
Humans
Aged
biology
Helicobacter pylori
business.industry
Nitrotyrosine
Intestinal metaplasia
General Medicine
Middle Aged
medicine.disease
biology.organism_classification
Immunohistochemistry
Infectious Diseases
medicine.anatomical_structure
chemistry
Gastric Mucosa
Gastritis
Chronic Disease
Tyrosine
Female
medicine.symptom
business
Subjects
Details
- ISSN :
- 10834389
- Volume :
- 8
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Helicobacter
- Accession number :
- edsair.doi.dedup.....8be25438cbee6a1591afaf7eb1bf9b77