Back to Search
Start Over
Acral lesions in tuberous sclerosis complex: Insights into pathogenesis
- Source :
- Journal of the American Academy of Dermatology. 63:244-251
- Publication Year :
- 2010
- Publisher :
- Elsevier BV, 2010.
-
Abstract
- Background Patients with tuberous sclerosis complex (TSC) are predisposed to developing ungual fibromas and other acral lesions. Objective We sought to determine the numbers, types, and locations of acral skin lesions in TSC. Methods We examined and photographed 76 adult women with TSC. Results The age of the patients ranged from 20 to 69 years, with a mean age of 39 ± 11 years. Ungual fibromas were observed in 61 of 76 patients (80%). Periungual fibromas were more common than subungual fibromas, were more common on the feet than the hands, and showed the greatest frequency on the fifth toe. Longitudinal grooves in the nails occurred with or without a visible fibroma. Longitudinal short red streaks–lesions that we term "red comets"–were observed in 22 patients (29%). Longitudinal leukonychia was observed in 14 patients (18%). One patient had isolated digital overgrowth and one patient had pachydermodactyly. Limitations No men or children were included in this study. Conclusions Examination of patients for skin lesions of TSC could be improved by including inspection for longitudinal nail grooves, red comets, longitudinal leukonychia, and splinter hemorrhages in addition to ungual fibromas. The anatomic distribution of TSC ungual fibromas is not random and appears consistent with trauma-promoted tumor formation.
- Subjects :
- Adult
Pathology
medicine.medical_specialty
Fibroma
Dermatology
Skin Diseases
Article
Lesion
Nail Diseases
Young Adult
Tuberous sclerosis
Tuberous Sclerosis
medicine
Humans
Aged
Skin
Ungual
business.industry
Middle Aged
medicine.disease
Pachydermodactyly
body regions
stomatognathic diseases
medicine.anatomical_structure
Nails
Nail disease
Leukonychia
Nail (anatomy)
Female
medicine.symptom
business
Subjects
Details
- ISSN :
- 01909622
- Volume :
- 63
- Database :
- OpenAIRE
- Journal :
- Journal of the American Academy of Dermatology
- Accession number :
- edsair.doi.dedup.....8c096a834e8eecae28821e6c1d8a3a1a