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The effects of the interplay of genetics and early environmental risk on the course of internalizing symptoms from late childhood through adolescence
- Source :
- Development and Psychopathology. 28:225-237
- Publication Year :
- 2015
- Publisher :
- Cambridge University Press (CUP), 2015.
-
Abstract
- Internalizing symptoms during adolescence and beyond is a major public health concern, particularly because severe symptoms can lead to the diagnosis of a number of serious psychiatric conditions. This study utilizes a unique sample with a complex statistical method in order to explore Gene × Environment interactions found in internalizing symptoms during adolescence. Data for this study were drawn from a longitudinal prevention intervention study (n = 798) of Baltimore city school children. Internalizing symptom data were collected using self-report and blood or saliva samples genotyped using Affymetrix 6.0 microarrays. A major depression polygenic score was created for each individual using information from the major depressive disorder Psychiatric Genetics Consortium and used as a predictor in a latent trait–state–occasion model. The major depressive disorder polygenic score was a significant predictor of the stable latent trait variable, which captures time-independent phenotypic variability. In addition, an early childhood stressor of death or divorce was a significant predictor of occasion-specific variables. A Gene × Environment interaction was not a significant predictor of the latent trait or occasion variables. These findings support the importance of genetics on the stable latent trait portion of internalizing symptoms across adolescence.
- Subjects :
- Male
Multifactorial Inheritance
medicine.medical_specialty
Adolescent
Genotype
Anxiety
Young Adult
03 medical and health sciences
0302 clinical medicine
Risk Factors
Developmental and Educational Psychology
medicine
Humans
0501 psychology and cognitive sciences
Longitudinal Studies
Early childhood
Young adult
Child
Psychiatric genetics
Depression (differential diagnoses)
Genetics
Depressive Disorder, Major
Depression
Public health
05 social sciences
Stressor
medicine.disease
030227 psychiatry
Psychiatry and Mental health
Phenotype
Regression Analysis
Major depressive disorder
Female
Gene-Environment Interaction
medicine.symptom
Psychology
050104 developmental & child psychology
Subjects
Details
- ISSN :
- 14692198 and 09545794
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Development and Psychopathology
- Accession number :
- edsair.doi.dedup.....8c28aa76b758e62339f657a9aa5d2e2c