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Deoxynivalenol (Vomitoxin)-Induced Anorexia Is Induced by the Release of Intestinal Hormones in Mice

Authors :
Wenda Wu
Eugenie Nepovimova
Jiacai Wang
Jianming Yue
Xiuge Gao
Dawei Guo
Kamil Kuca
Source :
Toxins, Vol 13, Iss 512, p 512 (2021), Toxins, Volume 13, Issue 8
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

Deoxynivalenol (DON), also known as vomitoxin, is a mycotoxin that can cause antifeeding and vomiting in animals. However, the mechanism of DON inducing anorexia is complicated. Studies have shown that intestinal hormones play a significant part in the anorexia caused by DON. We adopted the “modeling of acute antifeeding in mice” as the basic experimental model, and used two methods of gavage and intraperitoneal injection to explore the effect of intestinal hormones on the antifeedant response induced by DON in mice. We found that 1 and 2.5 mg/kg·bw of DON can acutely induce anorexia and increase the plasma intestinal hormones CCK, PYY, GIP, and GLP-1 in mice within 3 h. Direct injection of exogenous intestinal hormones CCK, PYY, GIP, and GLP-1 can trigger anorexia behavior in mice. Furthermore, the PYY receptor antagonist JNJ-31020028, GLP-1 receptor antagonist Exendin(9-39), CCK receptor antagonist Proglumide, GIP receptor antagonist GIP(3-30)NH2 attenuated both intestinal hormone and DON-induced anorectic responses. These results indicate that intestinal hormones play a critical role in the anorexia response induced by DON.

Details

Language :
English
ISSN :
20726651
Volume :
13
Issue :
512
Database :
OpenAIRE
Journal :
Toxins
Accession number :
edsair.doi.dedup.....8c337ccd529f5a96bfb29c2d79155be0