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Deoxynivalenol (Vomitoxin)-Induced Anorexia Is Induced by the Release of Intestinal Hormones in Mice
- Source :
- Toxins, Vol 13, Iss 512, p 512 (2021), Toxins, Volume 13, Issue 8
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Deoxynivalenol (DON), also known as vomitoxin, is a mycotoxin that can cause antifeeding and vomiting in animals. However, the mechanism of DON inducing anorexia is complicated. Studies have shown that intestinal hormones play a significant part in the anorexia caused by DON. We adopted the “modeling of acute antifeeding in mice” as the basic experimental model, and used two methods of gavage and intraperitoneal injection to explore the effect of intestinal hormones on the antifeedant response induced by DON in mice. We found that 1 and 2.5 mg/kg·bw of DON can acutely induce anorexia and increase the plasma intestinal hormones CCK, PYY, GIP, and GLP-1 in mice within 3 h. Direct injection of exogenous intestinal hormones CCK, PYY, GIP, and GLP-1 can trigger anorexia behavior in mice. Furthermore, the PYY receptor antagonist JNJ-31020028, GLP-1 receptor antagonist Exendin(9-39), CCK receptor antagonist Proglumide, GIP receptor antagonist GIP(3-30)NH2 attenuated both intestinal hormone and DON-induced anorectic responses. These results indicate that intestinal hormones play a critical role in the anorexia response induced by DON.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
endocrine system
Proglumide
medicine.drug_class
Health, Toxicology and Mutagenesis
medicine.medical_treatment
Intraperitoneal injection
trichothecene
deoxynivalenol
Anorexia
Gastric Inhibitory Polypeptide
intestinal hormones
Toxicology
Cholecystokinin receptor
Piperazines
Article
Receptors, Gastrointestinal Hormone
mycotoxin
Gastrointestinal Hormones
03 medical and health sciences
Eating
Mice
0302 clinical medicine
Internal medicine
medicine
Animals
Chemistry
digestive, oral, and skin physiology
Antagonist
Feeding Behavior
Receptor antagonist
Peptide Fragments
030104 developmental biology
Endocrinology
anorexia
Benzamides
Anorectic
Medicine
Female
medicine.symptom
Trichothecenes
030217 neurology & neurosurgery
hormones, hormone substitutes, and hormone antagonists
medicine.drug
Hormone
Subjects
Details
- Language :
- English
- ISSN :
- 20726651
- Volume :
- 13
- Issue :
- 512
- Database :
- OpenAIRE
- Journal :
- Toxins
- Accession number :
- edsair.doi.dedup.....8c337ccd529f5a96bfb29c2d79155be0