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Toxoplasmosis and abortion: pro- and anti-inflammatory cytokines gene expression of the host immune cells
- Source :
- Egyptian Journal of Medical Human Genetics, Vol 20, Iss 1, Pp 1-10 (2019)
- Publication Year :
- 2019
- Publisher :
- SpringerOpen, 2019.
-
Abstract
- Background Toxoplasmosis during pregnancy is known for inducing variable serious outcomes. In many previous studies, pregnancy was evaluated as a single event while in reality; it has different distinct immunological stages depending on gestational time and possible external factors as infectious agents. A state of immunological balance as well as a state of maternal-fetal tolerance should be established; otherwise, atypical unwelcomed outcomes might occur as a result of such infection Aim This work aimed to study the gene expression profile of some pro- and anti-inflammatory cytokines in Toxoplasma seropositive cases Results All studied cytokines were significantly upregulated in group I, with a remarkable bias towards IFN-γ, denoting a predominant inflammatory state in group I. In group II; tested cytokines were approximately in a balanced state with a little shift towards anti-inflammatory cytokines (IL-10 and TGF-β). A significant positive correlation was detected between pro-inflammatory together (p = 0.002, r = 0.96) and between anti-inflammatory cytokines together (p = 0.0008, r = 0.99) in group II, indicating the harmonized and synchronized expression of both pro- and anti-inflammatory cytokines. In group III, IL-10 was relatively higher with negative correlation with IFN-γ (p = 0.006, r = 0.93), indicating the possible role of IL10 in saving some of the pregnancies’ outcomes in group III. Conclusion The present study suggests a potential role of these cytokines in the upcoming prognostic or/and therapeutic concerns of toxoplasmosis among pregnant women.
- Subjects :
- 0301 basic medicine
TGF-β
lcsh:QH426-470
q-PCR
03 medical and health sciences
0302 clinical medicine
Immune system
Downregulation and upregulation
Gene expression
medicine
IFN-γ
Genetics (clinical)
Pregnancy
lcsh:R5-920
business.industry
medicine.disease
Toxoplasmosis
Interleukin 10
lcsh:Genetics
030104 developmental biology
Real-time polymerase chain reaction
030220 oncology & carcinogenesis
TNF-α
Immunology
Gestation
business
lcsh:Medicine (General)
Toxoplasma
IL10
Subjects
Details
- Language :
- English
- ISSN :
- 20902441
- Volume :
- 20
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Egyptian Journal of Medical Human Genetics
- Accession number :
- edsair.doi.dedup.....8c3b6ca21232512c5f45a80b06b95ae4