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Repeated, moderate footshock reduces the propensity to relapse to alcohol seeking in female, but not male, iP rats
- Source :
- Behavioral Neuroscience. 135:771-781
- Publication Year :
- 2021
- Publisher :
- American Psychological Association (APA), 2021.
-
Abstract
- Persistent alcohol use despite negative consequences is a key feature of alcohol use disorder (AUD) and is typically assessed using punishment in animal models. This study examined relapse-like behavior in male and female alcohol-preferring iP rats following punishment-imposed voluntary abstinence to alcohol seeking. We focused on alcohol seeking in the punishment-associated environment after prolonged abstinence. Finally, we sought to understand the predictability of relapse-like behavior by examining AUD comorbidities, namely, anxiety-like behavior and the response to repeated, moderate punishment. We found no sex differences in operant self-administration of alcohol. However, we did find a reduced propensity to relapse in the punishment-associated environment in female rats following prolonged abstinence. Relapse propensity was associated with the response to punishment during operant training, but not prior anxiety-like behavior. Together these results highlight the importance of studying sex differences in relapse to alcohol seeking. In addition, the behavioral response to a negative consequence may be a predictor of relapse, particularly in females. Improving our understanding of the sexually dimorphic responses in alcohol seeking may be a powerful tool for designing personalized, or at least sex-specific, approaches to treatment and rehabilitation programs. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
- Subjects :
- Male
Alcohol Drinking
Punishment (psychology)
medicine.medical_treatment
media_common.quotation_subject
education
Self Administration
Alcohol
Alcohol use disorder
PsycINFO
Behavioral Neuroscience
chemistry.chemical_compound
Punishment
Recurrence
medicine
Animals
Alcohol seeking
media_common
Rehabilitation
Ethanol
business.industry
Abstinence
medicine.disease
Rats
Behavioral response
chemistry
Conditioning, Operant
Female
business
Clinical psychology
Subjects
Details
- ISSN :
- 19390084 and 07357044
- Volume :
- 135
- Database :
- OpenAIRE
- Journal :
- Behavioral Neuroscience
- Accession number :
- edsair.doi.dedup.....8c4286d93982b2753d00c430966b04c1
- Full Text :
- https://doi.org/10.1037/bne0000486