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Potential health benefits of zinc supplementation for the management of COVID‐19 pandemic
- Source :
- Journal of Food Biochemistry
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is the etiological agent for the Coronavirus Disease 2019 (COVID‐19). The COVID‐19 pandemic has created unimaginable and unprecedented global health crisis. Since the outbreak of COVID‐19, millions of dollars have been spent, hospitalization overstretched with increasing morbidity and mortality. All these have resulted in unprecedented global economic catastrophe. Several drugs and vaccines are currently being evaluated, tested, and administered in the frantic efforts to stem the dire consequences of COVID‐19 with varying degrees of successes. Zinc possesses potential health benefits against COVID‐19 pandemic by improving immune response, minimizing infection and inflammation, preventing lung injury, inhibiting viral replication through the interference of the viral genome transcription, protein translation, attachment, and host infectivity. However, this review focuses on the various mechanisms of action of zinc and its supplementation as adjuvant for vaccines an effective therapeutic regimen in the management of the ravaging COVID‐19 pandemic. Practical applications The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the etiological agent for the Coronavirus Disease 2019 (COVID‐19), has brought unprecedented untold hardship to both developing and developed countries. The global race for vaccine development against COVID‐19 continues with success in sight with attendant increasing hospitalization, morbidity, and mortality. Available drugs with anti‐inflammatory actions have become alternative to stem the tide of COVID‐19 with attendant global financial crises. However, Zinc is known to modulate several physiological functions including intracellular signaling, enzyme function, gustation, and olfaction, as well as reproductive, skeletal, neuronal, and cardiovascular systems. Hence, achieving a significant therapeutic approach against COVID‐19 could imply the use of zinc as a supplement together with available drugs and vaccines waiting for emergency authorization to win the battle of COVID‐19. Together, it becomes innovative and creative to supplement zinc with currently available drugs and vaccines.<br />Dietary supplementation of Zinc could, therefore, be of immense benefits during the COVID‐19 pandemic due to its array of biological and pharmacological properties which include anti‐inflammatory, antioxidant, antiflu, antimicrobial, wound healing, antiaging, and a signaling molecule. Drugs such as chloroquine, and flavonoids including quercetin and epigallocatechin‐gallate act as facilitators and enhance the entry of zinc into the cell, and are, therefore, known as zinc ionophores. Hence, combining Zn as part of drug regimen for COVID‐19 could offer significant therapeutic advantage for the successful management of global COVID‐19 crisis.
- Subjects :
- medicine.medical_specialty
antioxidant
030309 nutrition & dietetics
Anti-Inflammatory Agents
Biophysics
Reviews
Review
Genome, Viral
Lung injury
Antiviral Agents
SARS‐CoV‐2
Antioxidants
03 medical and health sciences
Therapeutic approach
0404 agricultural biotechnology
Pharmacotherapy
Immune system
Pandemic
Global health
medicine
Humans
Intensive care medicine
Pandemics
immunomodulatory
Pharmacology
0303 health sciences
business.industry
SARS-CoV-2
zinc supplementation
Outbreak
COVID-19
04 agricultural and veterinary sciences
Cell Biology
040401 food science
antiviral
COVID-19 Drug Treatment
Zinc
Immune System
Dietary Supplements
business
Cytokine Release Syndrome
Developed country
Food Science
Subjects
Details
- Language :
- English
- ISSN :
- 17454514 and 01458884
- Database :
- OpenAIRE
- Journal :
- Journal of Food Biochemistry
- Accession number :
- edsair.doi.dedup.....8c4347f1595f22505bd31ae2963d7d95
- Full Text :
- https://doi.org/10.1111/jfbc.13604