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Stem cell transplantation for paediatric patients with non-anaplastic peripheral T-cell lymphoma in Japan
- Source :
- British Journal of Haematology. 159:88-93
- Publication Year :
- 2012
- Publisher :
- Wiley, 2012.
-
Abstract
- Summary Reports of non-anaplastic peripheral T-cell lymphoma (PTCL) in paediatric patients, especially results of stem cell transplantation (SCT), are relatively rare. We herein report the results of SCT using the Transplant Registry Unified Management Program system of the Japanese Society of Stem Cell Transplantation in paediatric patients with non-anaplastic PTCL. We analysed 26 patients (13 females and 13 males) aged 18 years with nonanaplastic PTCL who underwent a total of 28 SCT. Median age at transplantation was 135 years (range: 0–18 years). PTCL not otherwise specified was diagnosed in 17 patients; extranodal Natural Killer (NK)/T cell lymphoma, nasal type in nine; and subcutaneous panniculitis-like T-cell lymphoma in two. Transplantation was with syngeneic donor in one, related donor in 10; unrelated donor in 10; and auto transplantation in 7. Fiveyear overall survival rate and event-free survival rate was 6296% and 5556%, respectively. Male gender, chronic graft-versus-host disease (GVHD), and reduced intensity conditioning were good prognostic factors in all patients. In 20 patients with refractory or relapsed disease, male gender and chronic GVHD were also good prognostic factors. This study is the first report concerning transplantation in children with non-anaplastic PTCL, although the number of patients was small. Larger studies are needed to confirm these findings.
- Subjects :
- Male
Oncology
medicine.medical_specialty
Adolescent
T cell
Disease-Free Survival
Japan
Internal medicine
medicine
Humans
T-cell lymphoma
Child
Survival rate
business.industry
Not Otherwise Specified
Infant, Newborn
Infant
Lymphoma, T-Cell, Peripheral
Hematology
medicine.disease
Peripheral T-cell lymphoma
Surgery
Lymphoma
Survival Rate
Transplantation
surgical procedures, operative
medicine.anatomical_structure
Child, Preschool
Female
Stem cell
business
Stem Cell Transplantation
Subjects
Details
- ISSN :
- 00071048
- Volume :
- 159
- Database :
- OpenAIRE
- Journal :
- British Journal of Haematology
- Accession number :
- edsair.doi.dedup.....8c4daffcd2cbcb238df832bdb3beb15f