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Effects of different doses and serotypes of LPS on blood-brain barrier permeability in Sprague-Dawley rats
- Source :
- Critical Care
- Publication Year :
- 2013
- Publisher :
- Springer Science and Business Media LLC, 2013.
-
Abstract
- The blood-brain barrier (BBB) is highly restrictive of the transport of substances between blood and the central nervous system. Lipopolysaccharide (LPS) from Gram-negative bacteria was reported to affect the permeability of the BBB. BBB disruption using a LPS is used as a model of septic encephalopathy in mice. The present study was designed to investigate the effects of different doses and serotypes of LPS on BBB integrity in Sprague-Dawley rats.
- Subjects :
- Serotype
Pathology
medicine.medical_specialty
Lipopolysaccharide
business.industry
Central nervous system
Pharmacology
Critical Care and Intensive Care Medicine
Septic encephalopathy
chemistry.chemical_compound
medicine.anatomical_structure
nervous system
chemistry
Permeability (electromagnetism)
Poster Presentation
cardiovascular system
Sprague dawley rats
medicine
Blood brain barrier permeability
business
Subjects
Details
- ISSN :
- 13648535
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Critical Care
- Accession number :
- edsair.doi.dedup.....8c600a7f3d66aafe18ee71c41cc78f80
- Full Text :
- https://doi.org/10.1186/cc11959