Back to Search
Start Over
Alzheimer's Disease: Advances in Drug Development
- Source :
- Journal of Alzheimer's Disease, Journal of Alzheimer's Disease, IOS Press, 2018, 65 (1), pp.3-13. ⟨10.3233/JAD-180145⟩
- Publication Year :
- 2018
- Publisher :
- HAL CCSD, 2018.
-
Abstract
- International audience; As of 2018, Alzheimer's disease (AD) is the most common form of neurodegenerative dementia. It contributes to a progressive neuron loss, deterioration of memory, and cognitive impairment. Current therapies may provide a symptomatic benefit, but do not treat the underlying process. Ongoing researches focus on understanding the causal mechanisms and finding neuropathological hallmarks of AD. Therapeutic approaches targeting senile plaques or neurofibrillary tangles have not yet resulted in a significant cognitive improvement. However, recent data according to the analysis of AD clinical trials (clinicaltrials.gov database) show promising results. This literature review aims at summarizing the recent advances and at highlighting the most promising results of the ongoing researches. It compares the merits of small-molecules, antibodies, cell, and gene-based therapies and emphasizes the need for treatment at earlier stages of the disease.
- Subjects :
- 0301 basic medicine
early onset
Disease
tau proteins
amyloid-β peptides
Neuron loss
cell- and tissue-based therapy
03 medical and health sciences
0302 clinical medicine
Drug Development
Alzheimer Disease
Humans
Medicine
Senile plaques
Cognitive impairment
business.industry
General Neuroscience
amyloid-β protein precursor secretases
Cognition
General Medicine
3. Good health
Clinical trial
Psychiatry and Mental health
Clinical Psychology
030104 developmental biology
Drug development
[SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health
immunotherapy
Geriatrics and Gerontology
Neurodegenerative dementia
business
Neuroscience
Alzheimer’s disease
030217 neurology & neurosurgery
genetic therapy
Antipsychotic Agents
Subjects
Details
- Language :
- English
- ISSN :
- 13872877
- Database :
- OpenAIRE
- Journal :
- Journal of Alzheimer's Disease, Journal of Alzheimer's Disease, IOS Press, 2018, 65 (1), pp.3-13. ⟨10.3233/JAD-180145⟩
- Accession number :
- edsair.doi.dedup.....8c71e4827bf780e1421b057d1781aa67