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miR-370 is stage-specifically expressed during mouse embryonic development and regulates Dnmt3a
- Source :
- FEBS letters. 587(6)
- Publication Year :
- 2012
-
Abstract
- MicroRNAs (miRNAs) are small non-coding RNAs that participate in a large variety of biological processes. In this paper, the spatiotemporal expression pattern of miR-370 was characterized during mouse embryonic development, and was found to be stage- and tissue-specifically expressed. In addition, through luciferase reporter assays and western blot analyses, DNA methyltransferase 3A (Dnmt3a) was identified as a directly regulated target of miR-370. Altogether, our results indicate that miR-370 may play important roles in the morphogenesis of diverse organs, especially brain and adrenal glands, by mediating Dnmt3a expression during mouse development.
- Subjects :
- Time Factors
Molecular Sequence Data
Biophysics
Morphogenesis
Spatiotemporal expression
Dnmt3a
Biology
Biochemistry
DNA Methyltransferase 3A
Mice
miR-370
Western blot
Structural Biology
Genes, Reporter
microRNA
Adrenal Glands
Genetics
medicine
Animals
DNA (Cytosine-5-)-Methyltransferases
Luciferases
Molecular Biology
Gene
Regulation of gene expression
Mice, Inbred ICR
medicine.diagnostic_test
Base Sequence
Embryogenesis
Brain
Gene Expression Regulation, Developmental
Embryo
Cell Biology
Embryo, Mammalian
Molecular biology
MicroRNAs
Organ Specificity
Embryonic development
Female
Signal transduction
Signal Transduction
Subjects
Details
- ISSN :
- 18733468
- Volume :
- 587
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- FEBS letters
- Accession number :
- edsair.doi.dedup.....8c8deb46467b35fdf01bcbe3cf309f97