MPN-311 Clinical Case of Clonal Hemopoiesis in Patient With Splenectomy in Childhood

There is a subset of patients in the population who have undergone splenectomy for various reasons. Normally one of the spleen's functions is to eliminate defective blood cells and the impact of splenectomy on hematopoiesis is not clear yet.A patient born in 1993 with verified Minkowski-Chauffard's disease in 2005 is known to have a history of splenectomy at the age of 13 without any complications. The blood tests have been stable with minor deviations. In November 2016 patient consulted a hematologist due to complete blood count (CBC) which showed thrombocytosis (PLT -1101×10This patient with splenectomy in childhood developed clonal hemopoiesis though there were no diagnostic criteria of MPN.Splenectomy is frequently associated with thrombocytosis, its management and long-term outcomes in connection with diminished clonal hematopoiesis clearance are not yet well established.