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Reduced Oxidative Stress and Enhanced FGF21 Formation in Livers of Endurance-Exercised Rats with Diet-Induced NASH
- Source :
- Nutrients, Volume 11, Issue 11, Nutrients, Vol 11, Iss 11, p 2709 (2019)
- Publication Year :
- 2019
-
Abstract
- Non-alcoholic fatty liver diseases (NAFLD) including the severe form with steatohepatitis (NASH) are highly prevalent ailments to which no approved pharmacological treatment exists. Dietary intervention aiming at 10% weight reduction is efficient but fails due to low compliance. Increase in physical activity is an alternative that improved NAFLD even in the absence of weight reduction. The underlying mechanisms are unclear and cannot be studied in humans. Here, a rat NAFLD model was developed that reproduces many facets of the diet-induced NAFLD in humans. The impact of endurance exercise was studied in this model. Male Wistar rats received control chow or a NASH-inducing diet rich in fat, cholesterol, and fructose. Both diet groups were subdivided into a sedentary and an endurance exercise group. Animals receiving the NASH-inducing diet gained more body weight, got glucose intolerant and developed a liver pathology with steatosis, hepatocyte hypertrophy, inflammation and fibrosis typical of NAFLD or NASH. Contrary to expectations, endurance exercise did not improve the NASH activity score and even enhanced hepatic inflammation. However, endurance exercise attenuated the hepatic cholesterol overload and the ensuing severe oxidative stress. In addition, exercise improved glucose tolerance possibly in part by induction of hepatic FGF21 production.<br />Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe, 807
- Subjects :
- Blood Glucose
Male
Dietary Sugars
Down-Regulation
lcsh:TX341-641
Fructose
endurance exercise
Diet, High-Fat
digestive system
Article
FGF21
Non-alcoholic Fatty Liver Disease
Physical Conditioning, Animal
NAFLD
Animals
ddc:610
Rats, Wistar
NASH
nutritional and metabolic diseases
cholesterol
digestive system diseases
Exercise Therapy
Fibroblast Growth Factors
Disease Models, Animal
Oxidative Stress
Liver
glucose intolerance
Physical Endurance
Institut für Ernährungswissenschaft
lcsh:Nutrition. Foods and food supply
Signal Transduction
Subjects
Details
- ISSN :
- 20726643
- Volume :
- 11
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Nutrients
- Accession number :
- edsair.doi.dedup.....8c97484f9716afdb777390ae7bd8f293