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Microbiome in Blood Samples From the General Population Recruited in the MARK-AGE Project: A Pilot Study
- Source :
- FRONTIERS IN MICROBIOLOGY, Frontiers in Microbiology, Frontiers in Microbiology, Vol 12 (2021), Frontiers in Microbiology, 12. FRONTIERS MEDIA SA
- Publication Year :
- 2021
- Publisher :
- Frontiers Media SA, 2021.
-
Abstract
- The presence of circulating microbiome in blood has been reported in both physiological and pathological conditions, although its origins, identities and function remain to be elucidated. This study aimed to investigate the presence of blood microbiome by quantitative real-time PCRs targeting the 16S rRNA gene. To our knowledge, this is the first study in which the circulating microbiome has been analyzed in such a large sample of individuals since the study was carried out on 1285 Randomly recruited Age-Stratified Individuals from the General population (RASIG). The samples came from several different European countries recruited within the EU Project MARK-AGE in which a series of clinical biochemical parameters were determined. The results obtained reveal an association between microbial DNA copy number and geographic origin. By contrast, no gender and age-related difference emerged, thus demonstrating the role of the environment in influencing the above levels independent of age and gender at least until the age of 75. In addition, a significant positive association was found with Free Fatty Acids (FFA) levels, leukocyte count, insulin, and glucose levels. Since these factors play an essential role in both health and disease conditions, their association with the extent of the blood microbiome leads us to consider the blood microbiome as a potential biomarker of human health. publishedVersion
- Subjects :
- 0301 basic medicine
Microbiology (medical)
insulin
leukocytes
medicine.medical_treatment
Population
Physiology
geographic origin
Disease
Biology
Microbiology
03 medical and health sciences
Human health
0302 clinical medicine
ddc:570
medicine
Microbiome
glucose
education
Pathological
1183 Plant biology, microbiology, virology
Original Research
education.field_of_study
318 Medical biotechnology
Insulin
aging
free fatty acids
QR1-502
blood microbiome
030104 developmental biology
Potential biomarkers
Geographic origin
blood microbiome, 16S rRNA gene, geographic origin, aging, free fatty acids, leukocytes, insulin, glucose
3111 Biomedicine
16S rRNA gene
030217 neurology & neurosurgery
free fatty acid
Subjects
Details
- ISSN :
- 1664302X
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Frontiers in Microbiology
- Accession number :
- edsair.doi.dedup.....8cb28f7d4bf9a68ae5e2df30f415c128