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Serum Albumin Concentrations in Stable Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis
- Source :
- Journal of Clinical Medicine, Journal of Clinical Medicine, Vol 10, Iss 269, p 269 (2021)
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Background: Chronic obstructive pulmonary disease (COPD) is a progressive condition characterized by chronic airway inflammation and lung parenchyma damage. Systemic inflammation and oxidative stress also play a role in the pathogenesis of COPD. Serum albumin is a negative acute-phase protein with antioxidant effects and an important marker of malnutrition. The aim of this meta-analysis was to investigate differences in serum albumin concentrations between patients with stable COPD and non-COPD subjects. Methods: A systematic search was conducted, using the terms “albumin” and “chronic obstructive pulmonary disease” or “COPD”, in the electronic databases PubMed and Web of Science, from inception to May 2020. Results: Twenty-six studies were identified on a total of 2554 COPD patients and 2055 non-COPD controls. Pooled results showed that serum albumin concentrations were significantly lower in COPD patients (standard mean difference, SMD = −0.50, 95% CI −0.67 to −0.32; p < 0.001). No significant differences were observed in SMD of serum albumin concentrations between COPD patients with forced expiratory volume in the 1st second (FEV1) < 50% and those with FEV1 > 50%. Conclusions: Our systematic review and meta-analysis showed that serum albumin concentrations are significantly lower in patients with stable COPD compared to non-COPD controls. This supports the presence of a deficit in systemic anti-inflammatory and antioxidant defense mechanisms in COPD.
- Subjects :
- medicine.medical_specialty
Serum albumin
lcsh:Medicine
Inflammation
Review
malnutrition
medicine.disease_cause
Systemic inflammation
Gastroenterology
Pathogenesis
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
COPD
oxidative stress
030212 general & internal medicine
albumin
biology
business.industry
lcsh:R
Albumin
General Medicine
medicine.disease
respiratory tract diseases
030228 respiratory system
inflammation
Meta-analysis
biology.protein
medicine.symptom
business
Oxidative stress
Subjects
Details
- ISSN :
- 20770383
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Medicine
- Accession number :
- edsair.doi.dedup.....8cd2231e47e10a5361f8cbfb2d7ad8d2