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Use and safety of remdesivir in kidney transplant recipients with COVID-19
- Source :
- Dipòsit Digital de la UB, Universidad de Barcelona, Scientia, Kidney International Reports, Repositorio Abierto de la UdL, Universitad de Lleida
- Publication Year :
- 2021
- Publisher :
- Elsevier, 2021.
-
Abstract
- Introduction:Remdesivir has demonstrated antiviral activity against coronavirus, shortening the time torecovery in adults hospitalized with moderate/severe COVID-19. Severe adverse events such as acutekidney injury have been reported. Scant data are available on the use and safety of remdesivir in kidneytransplant recipients.Methods:We present a multicenter cohort study of 51 kidney transplant recipients with COVID-19 treatedwith remdesivir. Outcomes and safety were assessed.Results:Mean age at diagnosis was 60 years, with a median time since kidney transplant of 4.5years. Mean time since admission to remdesivir was 2 days. Twenty-eight patients (54.9%) requiredmechanical ventilation (19 noninvasive). Mortality was 18.9% and markedly higher if aged$65 years(45% vs. 3.2% in younger patients). Acute kidneyinjury was present in 27.7% of patients, but wasdiagnosed in 50% before treatment. No patients required remdesivir discontinuation because ofadverse events. We did notfind significant hepatoxicity or systemicsymptoms resulting from thedrug. Conclusion:In our cohort of kidney transplant recipients, remdesivir was well tolerated and safe in renaland hepatic toxicity, but randomized trials are needed to assess its efficacy. The authors are indebted to the many physicians andnurses who take care of these patients and are facing theCOVID-19 pandemic in our country. This research wassupported by Rio Hortega contract CM19/00004 (ISCIII)(AB), and RD16/0009/0013 (ISCIII FEDER RedinRen). MJP-S is supported by a Spanish Society of Transplantscholarship
- Subjects :
- medicine.medical_specialty
enfermedades urogenitales masculinas::enfermedades urológicas::enfermedades renales::insuficiencia renal::lesión renal aguda [ENFERMEDADES]
medicine.medical_treatment
Trasplantament renal
Remdesivir
Otros calificadores::Otros calificadores::/farmacoterapia [Otros calificadores]
Injury
Other subheadings::Other subheadings::/drug therapy [Other subheadings]
law.invention
Kidney transplantation
SARS-CoV2l
Randomized controlled trial
COVID-19 (Malaltia) - Tractament
law
Clinical Research
Internal medicine
medicine
virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus [ENFERMEDADES]
Adverse effect
business.industry
SARS-CoV-2
Acute kidney injury
diagnóstico::pronóstico::resultado del tratamiento [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS]
Immunosuppression
Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [DISEASES]
medicine.disease
Diagnosis::Prognosis::Treatment Outcome [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT]
Male Urogenital Diseases::Urologic Diseases::Kidney Diseases::Renal Insufficiency::Acute Kidney Injury [DISEASES]
Discontinuation
Insuficiència renal aguda
Nephrology
SARS-CoV2
Cohort
Avaluació de resultats (Assistència sanitària)
Acute kidney
business
Cohort study
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Dipòsit Digital de la UB, Universidad de Barcelona, Scientia, Kidney International Reports, Repositorio Abierto de la UdL, Universitad de Lleida
- Accession number :
- edsair.doi.dedup.....8cdc51c2c636a142b6db03dcb01ada0c