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Alcohol, tobacco, and mammographic density: a population-based study
- Source :
- Breast Cancer Research and Treatment, Breast Cancer Research and Treatment, Springer Verlag, 2011, 129 (1), pp.135-147. ⟨10.1007/s10549-011-1414-5⟩
- Publication Year :
- 2011
- Publisher :
- HAL CCSD, 2011.
-
Abstract
- International audience; Mammographic density (MD), or the proportion of the breast with respect to its overall area that is composed of dense tissue, is a strong risk factor for breast cancer. Studies support a positive association of mammographic density and alcohol drinking. This was a cross-sectional multicenter study based on 3584 women, aged 45-68 years, recruited from seven screening centers within the Spanish breast cancer screening program network. The association between MD, alcohol consumption and tobacco use was evaluated by using ordinal logistic models with random center-specific intercepts. We found a weak positive association between current alcohol intake and higher MD, with current alcohol consumption increasing the odds of high MD by 13% (OR = 1.13; 95% CI 0.99-1.28) and high daily grams of alcohol being positively associated with increased MD ( for trend = 0.045). There were no statistically significant differences in MD between smokers and non-smokers. Nevertheless, increased number of daily cigarettes and increased number of accumulated lifetime cigarettes were negatively associated with high MD ( for trend 0.017 and 0.021). The effect of alcohol on MD was modified by menopausal status and tobacco smoking: whereas, alcohol consumption and daily grams of alcohol were positively associated with higher MD in postmenopausal women and in women who were not currently smoking, alcohol consumption had no effect on MD in premenopausal women and current smokers. Our results support an association between recent alcohol consumption and high MD, characterized by a modest increase in risk at low levels of current consumption and a decrease in risk among heavier drinkers. Our study also shows how the effects of alcohol in the breast can be modified by other factors, such as smoking.
- Subjects :
- Cancer Research
medicine.medical_specialty
Alcohol Drinking
Breast Neoplasms
Alcohol
03 medical and health sciences
Breast cancer screening
chemistry.chemical_compound
0302 clinical medicine
Breast cancer
Risk Factors
Alcohol tobacco
medicine
Humans
030212 general & internal medicine
Risk factor
Mammographic density
Aged
Gynecology
medicine.diagnostic_test
business.industry
Smoking
MAMMOGRAPHIC DENSITY
Middle Aged
medicine.disease
3. Good health
Population based study
Cross-Sectional Studies
Oncology
chemistry
Spain
030220 oncology & carcinogenesis
Female
Alcohol intake
business
Ordinal logistic models
Mammography
Demography
Subjects
Details
- Language :
- English
- ISSN :
- 01676806 and 15737217
- Database :
- OpenAIRE
- Journal :
- Breast Cancer Research and Treatment, Breast Cancer Research and Treatment, Springer Verlag, 2011, 129 (1), pp.135-147. ⟨10.1007/s10549-011-1414-5⟩
- Accession number :
- edsair.doi.dedup.....8d001759d4d66f8323ad936287fec22a