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Phytochemical Characterization and Bioactivity of Asparagus acutifolius: A Focus on Antioxidant, Cytotoxic, Lipase Inhibitory and Antimicrobial Activities
- Source :
- Molecules, Digital.CSIC. Repositorio Institucional del CSIC, instname, Digital.CSIC: Repositorio Institucional del CSIC, Consejo Superior de Investigaciones Científicas (CSIC), Volume 26, Issue 11, Molecules, Vol 26, Iss 3328, p 3328 (2021)
- Publication Year :
- 2021
- Publisher :
- MDPI, 2021.
-
Abstract
- 19 Páginas.-- 5 Figuras.-- 5 Tablas<br />The phytochemical composition of leaves, stems, pericarps and rhizomes ethanolic extracts of Asparagus acutifolius were characterized by HPLC-DAD-MS. A. acutifolius samples contain at least eleven simple phenolics, one flavonon, two flavonols and six steroidal saponins. The stem extracts showed the highest total phenolic acid and flavonoid contents, where cafeic acid and rutin were the main compounds. No flavonoids were detected in the leaf, pericarp or rhizome while caffeic acid and ferulic acid were the predominant. Steroidal saponins were detected in the different plant parts of A. acutifolius, and the highest contents were found in the rhizome extracts. The stem extracts exhibited the highest antioxidant activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) and the highest 2,2-azino-bis (3 ethylbenzothiazoline-6-sulphonic acid) (ABTS) scavenging activity was found in the pericarp extracts. The rhizome and leaf extracts showed a potent cytotoxic activity against HCT-116 and HepG2 cell lines. Moreover, the pericarp and rhizome extracts revealed a moderate lipase inhibitory activity. The leaf and rhizome extracts were screened for their antimicrobial activity against human pathogenic isolates. The leaf extract exhibited a powerful inhibitory activity against all the bacteria and fungi tested.<br />This research was funded by the Tunisian Ministry of Scientific Research and Technology and by the Ministerio de Ciencia e Innovación of Spain (AGL2017-82428-R).
- Subjects :
- DPPH
Cytotoxicity
Asparagus acutifolius
Phytochemicals
Pharmaceutical Science
antioxidant activity
Lipase inhibitory activity
Antimicrobial activity
HPLC-DAD
01 natural sciences
Antioxidants
Mass Spectrometry
Analytical Chemistry
Ferulic acid
chemistry.chemical_compound
QD241-441
Flavonols
Anti-Infective Agents
Drug Discovery
Caffeic acid
Chromatography, High Pressure Liquid
chemistry.chemical_classification
ABTS
Traditional medicine
biology
Plant Stems
food and beverages
04 agricultural and veterinary sciences
Hep G2 Cells
040401 food science
Chemistry (miscellaneous)
Organ Specificity
Molecular Medicine
cytotoxicity
HPLC/Q-TOF-MS
Asparagus Plant
Cell Survival
lipase inhibitory activity
Antineoplastic Agents
Article
0404 agricultural biotechnology
Antioxidant activity
Humans
Physical and Theoretical Chemistry
Cell Proliferation
antimicrobial activity
010401 analytical chemistry
Organic Chemistry
Phenolic acid
Lipase
biology.organism_classification
HCT116 Cells
phytochemicals
0104 chemical sciences
Rhizome
LC-MS
Plant Leaves
chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 26
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....8d11e4a596add2dda6f746bfd27fb963