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Metabolic Risk Factors of Alzheimer’s Disease, Dementia with Lewy Bodies, and Normal Elderly: A Population-Based Study
- Source :
- Behavioural Neurology, Vol 2018 (2018), Behavioural Neurology
- Publication Year :
- 2018
- Publisher :
- Hindawi Limited, 2018.
-
Abstract
- Background. Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB) share many risk factors. Evidence suggests that metabolic risk factors are important to AD; however, their association with DLB is unclear. The risk of cardiovascular diseases (CVD) associated with AD and DLB is also uncertain. Thus, this nationwide, population-based study was designed to evaluate the metabolic and CVD risks in AD and DLB. Materials and Methods. Data were obtained from the Taiwan National Health Insurance Research Database. AD patients, DLB patients, and normal control (NC) individuals from 1996 to 2013 were enrolled for risk assessment. Results. In total, 7544 NC individuals, 1324 AD patients, and 562 DLB patients were enrolled. Participants with one or more metabolic risk factors had significantly higher odds of AD or DLB. No significant differences in metabolic risk factors were observed between DLB and AD patients. AD patients had a lower risk of CVD (aHR = 0.67, 95% CI = 0.59–0.76, p value p value p value Conclusion. Metabolic risk factors are important in AD and DLB. Patients with AD might have a lower risk of CAD and ischemic strokes. Patients with DLB might have a higher risk of ischemic stroke.
- Subjects :
- Lewy Body Disease
Male
0301 basic medicine
medicine.medical_specialty
Article Subject
Population
Neurosciences. Biological psychiatry. Neuropsychiatry
Disease
Neuropsychological Tests
Lower risk
behavioral disciplines and activities
Healthy Aging
03 medical and health sciences
0302 clinical medicine
Metabolic Diseases
Alzheimer Disease
Risk Factors
Internal medicine
mental disorders
medicine
Humans
education
Aged
Aged, 80 and over
education.field_of_study
Dementia with Lewy bodies
business.industry
Metabolic risk
General Medicine
Middle Aged
medicine.disease
nervous system diseases
Population based study
030104 developmental biology
Neuropsychology and Physiological Psychology
Neurology
National health insurance
Cardiovascular Diseases
Female
Neurology (clinical)
business
Risk assessment
030217 neurology & neurosurgery
Research Article
RC321-571
Subjects
Details
- Language :
- English
- ISSN :
- 18758584 and 09534180
- Volume :
- 2018
- Database :
- OpenAIRE
- Journal :
- Behavioural Neurology
- Accession number :
- edsair.doi.dedup.....8d1feaca4ef1b673f46a5bef0177a8e7