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Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals
- Source :
- Nat. Genet. 52, 1112-1121 (2018), Nature Genetics, Nature Genetics, 50(8), 1112-1121. Nature Publishing Group, 23Andme Research Team, Abdellaoui, A, Peyrot, W J, Hottenga, J J, Vinkhuyzen, A A E, Willemsen, G, Boomsma, D I, van Duijn, C M, Penninx, B, Posthuma, D & Uitterlinden, A G 2018, ' Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals ', Nature Genetics, vol. 50, no. 8, pp. 1112-1121 . https://doi.org/10.1038/s41588-018-0147-3, Nature Genetics, 50, 1112-1121, 2018, ' Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals ', Nature Genetics, vol. 50, no. 8, pp. 1112-+ . https://doi.org/10.1038/s41588-018-0147-3, Nature genetics, 50(8), 1112-1121. Nature Publishing Group, Nature Genetics, 50, 8, pp. 1112-1121, Nature Genetics, 50(8), 1112-+. Nature Publishing Group, 23andMe Research team 2018, ' Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals ', Nature Genetics, vol. 50, no. 8, pp. 1112-1121 . https://doi.org/10.1038/s41588-018-0147-3, 23andMe Research Team & Pendleton, N 2018, ' Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals ', Nature Genetics, vol. 50, no. 8, pp. 1112-1121 . https://doi.org/10.1038/s41588-018-0147-3
- Publication Year :
- 2018
- Publisher :
- Nature Publishing Group, 2018.
-
Abstract
- Contains fulltext : 195595.pdf (Publisher’s version ) (Open Access) Here we conducted a large-scale genetic association analysis of educational attainment in a sample of approximately 1.1 million individuals and identify 1,271 independent genome-wide-significant SNPs. For the SNPs taken together, we found evidence of heterogeneous effects across environments. The SNPs implicate genes involved in brain-development processes and neuron-to-neuron communication. In a separate analysis of the X chromosome, we identify 10 independent genome-wide-significant SNPs and estimate a SNP heritability of around 0.3% in both men and women, consistent with partial dosage compensation. A joint (multi-phenotype) analysis of educational attainment and three related cognitive phenotypes generates polygenic scores that explain 11-13% of the variance in educational attainment and 7-10% of the variance in cognitive performance. This prediction accuracy substantially increases the utility of polygenic scores as tools in research.
- Subjects :
- 0301 basic medicine
Male
Netherlands Twin Register (NTR)
Multifactorial Inheritance
genetic association
LOCI
Medizin
Genome-wide association study
INTELLIGENCE
Cohort Studies
0302 clinical medicine
GWAS
Genetics
Aged, 80 and over
Genome
HERITABILITY
HUMAN TRAITS
Middle Aged
HUMAN BRAIN
STATISTICS
3. Good health
Phenotype
Meta-analysis
Urological cancers Radboud Institute for Health Sciences [Radboudumc 15]
educational attainment
POPULATIONS
Educational Status
Female
genome-wide-significant SNPs
SDG 4 - Quality Education
Adult
Single-nucleotide polymorphism
Biology
Polymorphism, Single Nucleotide
Article
03 medical and health sciences
SNP
Humans
QH426
Behavioural genetics
METAANALYSIS
Aged
Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7]
Sequence Analysis, DNA
Heritability
Educational attainment
polygenic prediction
030104 developmental biology
Genome-Wide Association Study
MAPPING CAUSAL VARIANTS
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 10614036
- Database :
- OpenAIRE
- Journal :
- Nat. Genet. 52, 1112-1121 (2018), Nature Genetics, Nature Genetics, 50(8), 1112-1121. Nature Publishing Group, 23Andme Research Team, Abdellaoui, A, Peyrot, W J, Hottenga, J J, Vinkhuyzen, A A E, Willemsen, G, Boomsma, D I, van Duijn, C M, Penninx, B, Posthuma, D & Uitterlinden, A G 2018, ' Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals ', Nature Genetics, vol. 50, no. 8, pp. 1112-1121 . https://doi.org/10.1038/s41588-018-0147-3, Nature Genetics, 50, 1112-1121, 2018, ' Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals ', Nature Genetics, vol. 50, no. 8, pp. 1112-+ . https://doi.org/10.1038/s41588-018-0147-3, Nature genetics, 50(8), 1112-1121. Nature Publishing Group, Nature Genetics, 50, 8, pp. 1112-1121, Nature Genetics, 50(8), 1112-+. Nature Publishing Group, 23andMe Research team 2018, ' Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals ', Nature Genetics, vol. 50, no. 8, pp. 1112-1121 . https://doi.org/10.1038/s41588-018-0147-3, 23andMe Research Team & Pendleton, N 2018, ' Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals ', Nature Genetics, vol. 50, no. 8, pp. 1112-1121 . https://doi.org/10.1038/s41588-018-0147-3
- Accession number :
- edsair.doi.dedup.....8d23aa9d89404a0315f7a0c671918a03