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Tumor Multifocality is a Significant Risk Factor of Urinary Bladder Recurrence after Nephroureterectomy in Patients with Upper Tract Urothelial Carcinoma: A Single-Institutional Study
- Source :
- Diagnostics, Volume 10, Issue 4, Diagnostics, Vol 10, Iss 201, p 201 (2020)
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- The purpose of this study was to identify the significant risk factors of urinary bladder recurrence (UBR) after nephroureterectomy (NUx) in patients with upper tract urothelial carcinoma (UTUC). A total of 550 patients diagnosed with UTUC between January 2001 and December 2015 were included in this retrospective study. The median age of our patients was 68 (range 24&ndash<br />93) and the median follow-up time after NUx was 40.3 months (range 8&ndash<br />191). The most important censored point of this study was the first episode of UBR. Of the 550 patients, UBR occurred in 164 patients (29.8%). One hundred and forty-two (86.6%) patients with UBR were identified within two years after NUx for UTUC, with the median time interval between NUx and UBR being 8.4 months (range 3&ndash<br />59.8). Through univariate analysis, the positive surgical margin (p = 0.049) and tumor multifocality (p = 0.024) were both significant prognostic factors for UBR-free survival after NUx in patients with UTUC. However, only tumor multifocality (p = 0.037) remained a significant prognostic factor by multivariate analysis. In conclusion, tumor multifocality is a significant risk factor of UBR after nephroureterectomy in patients with upper tract urothelial carcinoma.
- Subjects :
- medicine.medical_specialty
recurrence
Multivariate analysis
Clinical Biochemistry
030232 urology & nephrology
Urology
Article
03 medical and health sciences
0302 clinical medicine
medicine
In patient
tumor multifocality
First episode
lcsh:R5-920
Univariate analysis
Urinary bladder
business.industry
nephroureterectomy
Retrospective cohort study
upper tract urothelial carcinoma
medicine.anatomical_structure
Upper tract
030220 oncology & carcinogenesis
Positive Surgical Margin
lcsh:Medicine (General)
business
urinary bladder
Subjects
Details
- ISSN :
- 20754418
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Diagnostics
- Accession number :
- edsair.doi.dedup.....8d63815ce84bf8171e8903802917324a