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Management of acute promyelocytic leukemia: updated recommendations from an expert panel of the European LeukemiaNet
- Source :
- Blood, r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe, instname, Blood, 133(15), 1630-1643. American Society of Hematology
- Publication Year :
- 2019
- Publisher :
- American Society of Hematology, 2019.
-
Abstract
- Since the comprehensive recommendations for the management of acute promyelocytic leukemia (APL) reported in 2009, several studies have provided important insights, particularly regarding the role of arsenic trioxide (ATO) in frontline therapy. Ten years later, a European LeukemiaNet expert panel has reviewed the recent advances in the management of APL in both frontline and relapse settings in order to develop updated evidence- and expert opinion–based recommendations on the management of this disease. Together with providing current indications on genetic diagnosis, modern risk-adapted frontline therapy, and salvage treatment, the review contains specific recommendations for the identification and management of the most important complications such as the bleeding disorder APL differentiation syndrome, QT prolongation, and other all-trans retinoic acid– and ATO-related toxicities, as well as recommendations for molecular assessment of the response to treatment. Finally, the approach to special situations is also discussed, including management of APL in children, elderly patients, and pregnant women. The most important challenges remaining in APL include early death, which still occurs before and during induction therapy, and optimizing treatment in patients with high-risk disease.
- Subjects :
- Acute promyelocytic leukemia
medicine.medical_specialty
medicine.medical_treatment
Immunology
MEDLINE
Tretinoin
Disease
Hemorrhagic Disorders
Biochemistry
Hemorrhagic disorder
European LeukemiaNet
Arsenic Trioxide
Leukemia, Promyelocytic, Acute
Pregnancy
Recurrence
Humans
Medicine
Disease management (health)
Intensive care medicine
Special Report
Neoadjuvant therapy
APL Differentiation Syndrome
Aged
business.industry
Disease Management
Cell Biology
Hematology
medicine.disease
Practice Guidelines as Topic
Female
business
Subjects
Details
- ISSN :
- 15280020 and 00064971
- Volume :
- 133
- Issue :
- 15
- Database :
- OpenAIRE
- Journal :
- Blood
- Accession number :
- edsair.doi.dedup.....8d6efaa5ddf376b7fc26ea7d8a87f0e2