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Characteristics of inflammatory bowel disease in patients of Roma/Gypsy ethnicity. A case-control study
- Source :
- Digestive and Liver Disease, r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol, instname, Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
- Publication Year :
- 2018
-
Abstract
- Background: Peculiarities of inflammatory bowel disease (IBD) have been explored in ethnic groups, such as Asians, Hispanics, and Afro-Americans, but not in other ethnic minorities, such as Roma/Gypsies. Methods: In a retrospective, hospital-based study, all adult Roma/Gypsy patients included in the IBD databases of seven Spanish centres were identified as cases. For each Roma/Gypsy patient, a Caucasian patient, matched for several demographic features, was searched as a control. Data on phenotypic features, therapeutic requirements, and familial aggregation were recorded. Results: Sixty-eight Roma/Gypsy patients were identified, 29 of them being women. The mean age at diagnosis of IBD was 24.9 +/- 9.5 years, and the mean time elapsed since diagnosis was 96.6 +/- 72.2 months. Roma/Gypsy IBD patients showed a significantly higher rate of familial aggregation (43%) than their Caucasian controls (9%) (p = 0.00001). CD in Roma/Gypsies had more often a complicated pattern (mainly penetrating) while UC patients showed a marked trend to more often developing extraintestinal manifestations. In addition, Roma/Gypsy IBD patients had a somewhat greater need for immunosuppressants, biological agents or surgery. Conclusions: These are the first data on IBD in Roma/Gypsy patients. Familial aggregation is the most prominent feature in these patients, suggesting a predominant role of genetics in its pathogenesis. (C) 2018 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
- Subjects :
- Adult
Male
medicine.medical_specialty
Roma
Adolescent
Databases, Factual
Ethnic group
Crohn's Disease
Inflammatory bowel disease
03 medical and health sciences
Young Adult
0302 clinical medicine
Internal medicine
medicine
Ulcerative Colitis
Humans
In patient
Crohn's disease
Hepatology
business.industry
Inflammatory Bowel Disease
Gastroenterology
Case-control study
Family aggregation
Mean age
Roma/Gypsy ethnicit
medicine.disease
Inflammatory Bowel Diseases
Ulcerative colitis
Phenotype
Spain
030220 oncology & carcinogenesis
Case-Control Studies
030211 gastroenterology & hepatology
Female
business
Immunosuppressive Agents
Subjects
Details
- ISSN :
- 18783562 and 15908658
- Volume :
- 51
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
- Accession number :
- edsair.doi.dedup.....8d7d6ce3faad30db56bbd9d083e7cb16