Back to Search
Start Over
Combination therapy of ecabet sodium and cimetidine compared with cimetidine alone for gastric ulcer: Prospective randomized multicenter study
- Source :
- Journal of Gastroenterology and Hepatology. 18:1029-1033
- Publication Year :
- 2003
- Publisher :
- Wiley, 2003.
-
Abstract
- Background and Aim: Little is known about the clinical efficacy of cotherapy of ecabet sodium, a mucoprotective agent, and a histamine H2-receptor antagonist. The aim of the present study was to assess its additive benefit in combination with cimetidine for gastric ulcer. Methods: In this prospective randomized study, after gastric ulcer was confirmed by endoscopy, 200 patients in 47 hospitals received either ecabet sodium 1 g b.i.d and cimetidine 400 mg b.i.d. (EC), or cimetidine 400 mg b.i.d. alone (C) for 8 weeks. Healing was examined by endoscopy at 4 and 8 weeks. Results: Of the intention-to-treat (ITT) population (EC, 103; C, 97), 181 patients comprised the per protocol (PP) analysis (EC, 93; C, 88). At 4 weeks, healing rates were significantly higher in the EC group (60%) than in the C group (36%) ( p
- Subjects :
- Adult
Male
medicine.medical_specialty
Time Factors
Randomization
Combination therapy
Population
Gastroenterology
law.invention
Randomized controlled trial
law
Internal medicine
medicine
Humans
Prospective Studies
Stomach Ulcer
Cimetidine
Prospective cohort study
education
Adverse effect
education.field_of_study
Hepatology
business.industry
Stomach
Middle Aged
Anti-Ulcer Agents
Surgery
medicine.anatomical_structure
Abietanes
Drug Therapy, Combination
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 14401746 and 08159319
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Journal of Gastroenterology and Hepatology
- Accession number :
- edsair.doi.dedup.....8da0539c24310741c20e585175d95950
- Full Text :
- https://doi.org/10.1046/j.1440-1746.2003.03093.x