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Combination therapy of ecabet sodium and cimetidine compared with cimetidine alone for gastric ulcer: Prospective randomized multicenter study

Authors :
Syouji Mitsufuji
G. Kajiyama
Sunao Kawano
Ichimonji Saito
Takenobu Kamada
Tadao Bamba
Masanori Inoue
Hironaka Kawasaki
Shingo Tsuji
Kyouichi Inoue
Yuuji Matsuzawa
Hiroaki Murata
Ken-ichi Katsu
Kenichi Kobayashi
Eiji Umegaki
Source :
Journal of Gastroenterology and Hepatology. 18:1029-1033
Publication Year :
2003
Publisher :
Wiley, 2003.

Abstract

Background and Aim: Little is known about the clinical efficacy of cotherapy of ecabet sodium, a mucoprotective agent, and a histamine H2-receptor antagonist. The aim of the present study was to assess its additive benefit in combination with cimetidine for gastric ulcer. Methods: In this prospective randomized study, after gastric ulcer was confirmed by endoscopy, 200 patients in 47 hospitals received either ecabet sodium 1 g b.i.d and cimetidine 400 mg b.i.d. (EC), or cimetidine 400 mg b.i.d. alone (C) for 8 weeks. Healing was examined by endoscopy at 4 and 8 weeks. Results: Of the intention-to-treat (ITT) population (EC, 103; C, 97), 181 patients comprised the per protocol (PP) analysis (EC, 93; C, 88). At 4 weeks, healing rates were significantly higher in the EC group (60%) than in the C group (36%) ( p

Details

ISSN :
14401746 and 08159319
Volume :
18
Database :
OpenAIRE
Journal :
Journal of Gastroenterology and Hepatology
Accession number :
edsair.doi.dedup.....8da0539c24310741c20e585175d95950
Full Text :
https://doi.org/10.1046/j.1440-1746.2003.03093.x