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Lack of Interaction between Levofloxacin and Oxycodone: Pharmacokinetics and Drug Disposition
Lack of Interaction between Levofloxacin and Oxycodone: Pharmacokinetics and Drug Disposition
- Source :
- The Journal of Clinical Pharmacology. 41:206-209
- Publication Year :
- 2001
- Publisher :
- Wiley, 2001.
-
Abstract
- Previous studies have demonstrated a significant reduction in the oral bioavailability of trovafloxacin and ciprofloxacin when administered concomitantly with an intravenous opiate such as morphine. This decrease in absorption results in a 36% and 50% lower AUC for trovafloxacin and ciprofloxacin, respectively, which could cause clinical failures. The authors investigated the possibility of a similar interaction between oxycodone and levofloxacin. Eight healthy volunteers were randomized in an open-label, two-way crossover study to receive oxycodone, 5 mg p.o. Q4H, and levofloxacin, 500 mg p.o. 1 hour after starting the oxycodone or levofloxacin 500 mg p.o. alone. Blood samples were drawn at 0, 0.5, 1, 1.5, 2, 3, 4, 6, 8, 12, 18, and 24 hours for Cmax, tmax, and AUC determinations. There was not a significant difference (p > 0.05) in AUC (48.59 +/- 8.52 vs. 49.9 +/- 9.93), Cmax (7.73 +/- 2.6 vs. 6.6 +/- 2.0), and tmax (1.1 +/- 0.6 vs. 1.6 +/- 1.1) for levofloxacin versus levofloxacin/oxycodone regimens. It was concluded that oral oxycodone and levofloxacin can be administered concomitantly without a significant decrease in AUC, Cmax, or tmax.
- Subjects :
- Adult
Male
Ofloxacin
Cmax
Levofloxacin
Pharmacology
Anti-Infective Agents
Pharmacokinetics
medicine
Humans
Drug Interactions
heterocyclic compounds
Pharmacology (medical)
Chromatography, High Pressure Liquid
Antibacterial agent
Cross-Over Studies
business.industry
biochemical phenomena, metabolism, and nutrition
Crossover study
Trovafloxacin
Antitussive Agents
Quinolines
Morphine
Female
business
Oxycodone
medicine.drug
Subjects
Details
- ISSN :
- 00912700
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- The Journal of Clinical Pharmacology
- Accession number :
- edsair.doi.dedup.....8dace31e4bfe4ec7a59daf6fcf32c206
- Full Text :
- https://doi.org/10.1177/00912700122009890