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Angiotensin II-Induced Signaling Pathways in Diabetes
- Source :
- Current Diabetes Reviews. 1:197-202
- Publication Year :
- 2005
- Publisher :
- Bentham Science Publishers Ltd., 2005.
-
Abstract
- Excessive cellular proliferation is a major contributor to the pathological changes associated with the secondary complications of diabetes. In particular, hyperglycemia (HG)-induced growth of vascular smooth muscle cells (VSMC) and glomerular mesangial cells (GMC) are characteristic features of the cardiovascular and renal complications of diabetes. VSMC and GMC respond to traditional growth factors, however in diabetes this occurs in the context of an environment, enriched in circulating vasoactive mediators and HG. For example, signaling via the angiotensin II (Ang II) pathway has been implicated in the pathogenesis of diabetic vascular disease. Recent findings indicate that HG and Ang II activate intracellular processes, including the polyol pathway and the generation of reactive oxygen species. These pathways activate the JAK (janus kinase)/STAT (signal transducers and activators of transcription) signaling cascades in both VSMC and GMC. Activation of the latter signaling cascade can stimulate excessive proliferation and growth of these cells, contributing to the accelerated atherosclerosis and nephropathy seen in the diabetic state. This review focuses on key factors in the diabetic microenvironment, in particular the interplay between HG, accumulation of advanced glycation end products and Ang II mediated signaling events both in vitro and in vivo.
- Subjects :
- Glycation End Products, Advanced
medicine.medical_specialty
Vascular smooth muscle
Endocrinology, Diabetes and Metabolism
Glomerular Mesangial Cell
Muscle, Smooth, Vascular
Endocrinology
Polyol pathway
Glycation
Internal medicine
Diabetes mellitus
Diabetes Mellitus
Humans
Medicine
Diabetic Nephropathies
business.industry
Angiotensin II
medicine.disease
Glomerular Mesangium
Hyperglycemia
Cancer research
Signal transduction
Reactive Oxygen Species
business
Janus kinase
Cell Division
Diabetic Angiopathies
Signal Transduction
Subjects
Details
- ISSN :
- 15733998
- Volume :
- 1
- Database :
- OpenAIRE
- Journal :
- Current Diabetes Reviews
- Accession number :
- edsair.doi.dedup.....8db31d7832ed9005a7c5993604a92bc7