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Mollemycin A: An Antimalarial and Antibacterial Glyco-hexadepsipeptide-polyketide from an Australian Marine-Derived Streptomyces sp. (CMB-M0244)
- Source :
- Organic Letters. 16:1716-1719
- Publication Year :
- 2014
- Publisher :
- American Chemical Society (ACS), 2014.
-
Abstract
- A marine-derived Streptomyces sp. (CMB-M0244) isolated from a sediment collected off South Molle Island, Queensland, produced mollemycin A (1) as a new first in class glyco-hexadepsipeptide-polyketide. The structure of 1 was assigned by detailed spectroscopic analysis, supported by chemical derivatization and degradation, and C3 Marfey's analysis. Mollemycin A (1) exhibits exceptionally potent and selective growth inhibitory activity against Gram-positive and Gram-negative bacteria (IC50 10-50 nM) and drug-sensitive (3D7; IC50 7 nM) and multidrug-resistant (Dd2; IC50 9 nM) clones of the malaria parasite Plasmodium falciparum.
- Subjects :
- Stereochemistry
Plasmodium falciparum
Streptomyces sp. CMB
Marine Biology
Growth inhibitory
Microbial Sensitivity Tests
Biochemistry
Streptomyces
Antimalarials
Inhibitory Concentration 50
Structure-Activity Relationship
Polyketide
chemistry.chemical_compound
Depsipeptides
Parasite hosting
Physical and Theoretical Chemistry
Derivatization
Nuclear Magnetic Resonance, Biomolecular
Molecular Structure
biology
Organic Chemistry
Australia
biology.organism_classification
Drug Resistance, Multiple
Anti-Bacterial Agents
chemistry
Polyketides
Bacteria
Subjects
Details
- ISSN :
- 15237052 and 15237060
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Organic Letters
- Accession number :
- edsair.doi.dedup.....8dbfebe2ee440ad02da1eab1d6289864