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Histomorphometric evaluation of short-term changes in masseter muscle after lengthening the rabbit mandible by distraction osteogenesis
- Source :
- Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons. 61(5)
- Publication Year :
- 2003
-
Abstract
- Purpose: Structural changes in muscles may affect the process during and after distraction osteogenesis (DO) of the mandible. However, the response of the masticatory muscles is still not well defined after gradual lengthening of the mandible. In this experimental study, short-term structural changes in masseter muscles of the rabbits are evaluated after mandibular DO. Materials and Methods: Left mandibles of 10 New Zealand rabbits were lengthened by DO for 7 days in the rate of 1 mm/day. Mandibles of all animals were removed at the end of the consolidation period. Muscle biopsy samples of distracted and contralateral sides were histopathologically investigated, and histomorphometric results were statistically analyzed. Results: Atrophy, hypertrophy, regeneration, and concomitant mild interstitial edema and fibrosis were found more evident in experimental side biopsy samples 30 days after distraction. Histomorphometric analysis revealed a statistically significant decrease in the mean regions of masseter muscle fibers of the distracted sides compared with the control sides ( P Conclusion: This experimental study showed that the structure of masseter muscle is influenced during and shortly after mandibular distraction osteogenesis. Atrophic changes of the ipsilateral masseter muscles may be regarded as regenerative response that occurs during and shortly after distraction period. © 2003 American Association of Oral and Maxillofacial Surgeons J Oral Maxillofac Surg 61:615-620, 2003
- Subjects :
- Time Factors
medicine.medical_treatment
Biopsy
Matched-Pair Analysis
Muscle Fibers, Skeletal
Osteogenesis, Distraction
Mandible
Muscle hypertrophy
Masseter muscle
Atrophy
medicine
Image Processing, Computer-Assisted
Animals
Edema
Regeneration
Cell Nucleus
Muscle biopsy
medicine.diagnostic_test
business.industry
Masseter Muscle
Anatomy
Hypertrophy
medicine.disease
Fibrosis
Masticatory force
Otorhinolaryngology
Connective Tissue
Distraction osteogenesis
Surgery
Rabbits
Oral Surgery
business
Subjects
Details
- ISSN :
- 02782391
- Volume :
- 61
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
- Accession number :
- edsair.doi.dedup.....8dc17b562a5f6ee1fd678de81eeb2e88