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The Bioenergetic Health Index: a new concept in mitochondrial translational research
- Source :
- Clinical Science (London, England : 1979)
- Publication Year :
- 2014
- Publisher :
- Portland Press Ltd., 2014.
-
Abstract
- Bioenergetics has become central to our understanding of pathological mechanisms, the development of new therapeutic strategies and as a biomarker for disease progression in neurodegeneration, diabetes, cancer and cardiovascular disease. A key concept is that the mitochondrion can act as the ‘canary in the coal mine’ by serving as an early warning of bioenergetic crisis in patient populations. We propose that new clinical tests to monitor changes in bioenergetics in patient populations are needed to take advantage of the early and sensitive ability of bioenergetics to determine severity and progression in complex and multifactorial diseases. With the recent development of high-throughput assays to measure cellular energetic function in the small number of cells that can be isolated from human blood these clinical tests are now feasible. We have shown that the sequential addition of well-characterized inhibitors of oxidative phosphorylation allows a bioenergetic profile to be measured in cells isolated from normal or pathological samples. From these data we propose that a single value–the Bioenergetic Health Index (BHI)–can be calculated to represent the patient's composite mitochondrial profile for a selected cell type. In the present Hypothesis paper, we discuss how BHI could serve as a dynamic index of bioenergetic health and how it can be measured in platelets and leucocytes. We propose that, ultimately, BHI has the potential to be a new biomarker for assessing patient health with both prognostic and diagnostic value.
- Subjects :
- haplotype
hepatotoxicity
Cell type
Bioenergetics
ETC, electron transport chain
Physiology
Translational research
S9
Disease
Biology
Mitochondrion
Bioinformatics
S4
Translational Research, Biomedical
RNS, reactive nitrogen species
neurodegenerative disease
ROS, reactive oxygen species
cardiovascular disease
Diabetes mellitus
reserve capacity
medicine
Animals
Humans
oxidative stress
OCR, oxygen consumption rate
HNE, hydroxynonenal
aging
Neurodegeneration
General Medicine
Hypothesis
medicine.disease
Mitochondria
mtDNA, mitochondrial DNA
3. Good health
Biomarker (cell)
FCCP, carbonyl cyanide p-trifluoromethoxyphenylhydrazone
BHI, Bioenergetic Health Index
Energy Metabolism
Biomarkers
LDA, linear discriminant analysis
Subjects
Details
- ISSN :
- 14708736 and 01435221
- Volume :
- 127
- Database :
- OpenAIRE
- Journal :
- Clinical Science
- Accession number :
- edsair.doi.dedup.....8ddf9afbb531579a1898dc1867b77a4d
- Full Text :
- https://doi.org/10.1042/cs20140101