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Peripheral blood neutrophil morphology reflects bone marrow dysplasia in myelodysplastic syndromes
- Source :
- American Journal of Hematology. 49:115-120
- Publication Year :
- 1995
- Publisher :
- Wiley, 1995.
-
Abstract
- Dysplastic features of cells in peripheral blood and bone marrow were studied in 51 patients with myelodysplastic syndromes (MDS) to evaluate the significance of the degree of neutrophil granulation (G-score) and the percentage of pelgeroid polymorphs (ppp) in the peripheral blood, as indices of dysplastic changes in the bone marrow. There was a good correlation between peripheral blood and bone marrow findings, both for G-score figures (r = 0.92, P0.01) and ppp (r = 0.82, P0.01). Significantly lower G-score figures were found among patients with an increased percentage of bone marrow blasts (P0.05), while high ppp correlated with the presence of ring sideroblasts, the degree of bone marrow fibrosis, and findings of complex chromosomal abnormalities. Patients with a high degree of bone marrow dysplasia had significantly lower G-score (P0.01) and significantly higher ppp (P0.05) figures, than those with less pronounced myelodysplasia. In addition, extreme hypogranulation (G-score150) or very high ppp (or = 20%) was generally a sign of bi- and tri-lineage dysplasia in the bone marrow. The results thus show that quantitative estimation of peripheral blood polymorph dysplasia by G-score figures and ppp seems to reflect the total degree of bone marrow dysplasia in MDS and may serve as a complement to bone marrow evaluation when the diagnosis of MDS is difficult.
- Subjects :
- Aged, 80 and over
Male
Cytoplasm
Pathology
medicine.medical_specialty
Total degree
Neutrophils
business.industry
Myelodysplastic syndromes
Hematology
Middle Aged
Granulocyte
medicine.disease
Peripheral blood
medicine.anatomical_structure
Bone Marrow
Dysplasia
Myelodysplastic Syndromes
medicine
Humans
Female
Bone marrow
Bone marrow dysplasia
business
Aged
Subjects
Details
- ISSN :
- 10968652 and 03618609
- Volume :
- 49
- Database :
- OpenAIRE
- Journal :
- American Journal of Hematology
- Accession number :
- edsair.doi.dedup.....8de8c414b4e90a28cddb200efda6752c