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Surface-Functionalized Nanoparticles by Olefin Metathesis: A Chemoselective Approach for In Vivo Characterization of Atherosclerosis Plaque
Surface-Functionalized Nanoparticles by Olefin Metathesis: A Chemoselective Approach for In Vivo Characterization of Atherosclerosis Plaque
- Source :
- Chemistry - A European Journal. 21:10450-10456
- Publication Year :
- 2015
- Publisher :
- Wiley, 2015.
-
Abstract
- The use of click chemistry reactions for the functionalization of nanoparticles is particularly useful to modify the surface in a well-defined manner and to enhance the targeting properties, thus facilitating clinical translation. Here it is demonstrated that olefin metathesis can be used for the chemoselective functionalization of iron oxide nanoparticles with three different examples. This approach enables, in one step, the synthesis and functionalization of different water-stable magnetite-based particles from oleic acid-coated counterparts. The surface of the nanoparticles was completely characterized showing how the metathesis approach introduces a large number of hydrophilic molecules on their coating layer. As an example of the possible applications of these new nanocomposites, a focus was taken on atherosclerosis plaques. It is also demonstrated how the in vitro properties of one of the probes, particularly its Ca(2+) -binding properties, mediate their final in vivo use; that is, the selective accumulation in atherosclerotic plaques. This opens promising new applications to detect possible microcalcifications associated with plaque vulnerability. The accumulation of the new imaging tracers is demonstrated by in vivo magnetic resonance imaging of carotids and aorta in the ApoE(-/-) mouse model and the results were confirmed by histology.
- Subjects :
- Contrast Media
Nanoparticle
Nanotechnology
Alkenes
engineering.material
Metathesis
Ferric Compounds
Catalysis
Mice
chemistry.chemical_compound
Coating
In vivo
Animals
Aorta
Nanocomposite
Organic Chemistry
General Chemistry
Atherosclerosis
Magnetic Resonance Imaging
Combinatorial chemistry
Plaque, Atherosclerotic
chemistry
engineering
Click chemistry
Nanoparticles
Surface modification
Click Chemistry
Iron oxide nanoparticles
Subjects
Details
- ISSN :
- 09476539
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Chemistry - A European Journal
- Accession number :
- edsair.doi.dedup.....8deafdc650fb123121b65bf50affbf0e
- Full Text :
- https://doi.org/10.1002/chem.201500458