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Treatment response heterogeneity in asthma: the role of genetic variation
- Source :
- Expert review of respiratory medicine. 12(1):55-65
- Publication Year :
- 2018
-
Abstract
- Introduction: Asthmatic patients show a large heterogeneity in response to asthma medication. Rapidly evolving genotyping technologies have led to the identification of various genetic variants associated with treatment outcomes.Areas covered: This review focuses on the current knowledge of genetic variants influencing treatment response to the most commonly used asthma medicines: short- and long-acting beta-2 agonists (SABA/LABA), inhaled corticosteroids (ICS) and leukotriene modifiers. This review shows that various genetic variants have been identified, but none are currently used to guide asthma treatment. One of the most promising genetic variants is the Arg16 variant in the ADRB2 gene to guide LABA treatment in asthmatic children.Expert commentary: Poor replication of initially promising results and the low fraction of variability accounted for by single genetic variants inhibit pharmacogenetic findings to reach the asthma clinic. Nevertheless, the identification of genetic variation influencing treatment response does provide more insights in the complex processes underlying response and might identify novel targets for treatment. There is a need to report measures of clinical validity, to perform precision-medicine guided trials, as well as to understand how genetic variation interacts with environmental factors. In addition, systems biology approaches might be able to show a more complete picture of these complex interactions
- Subjects :
- 0301 basic medicine
Pulmonary and Respiratory Medicine
Treatment response
03 medical and health sciences
0302 clinical medicine
Adrenal Cortex Hormones
Genetic variation
Administration, Inhalation
medicine
Immunology and Allergy
Asthmatic patient
Humans
Anti-Asthmatic Agents
Genotyping
Asthma
business.industry
Public Health, Environmental and Occupational Health
Genetic Variation
Asthma medication
medicine.disease
030104 developmental biology
Treatment Outcome
030228 respiratory system
Pharmacogenetics
Pharmacogenomics
Immunology
Leukotriene Antagonists
Receptors, Adrenergic, beta-2
business
Subjects
Details
- Language :
- English
- ISSN :
- 17476356
- Volume :
- 12
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Expert review of respiratory medicine
- Accession number :
- edsair.doi.dedup.....8df5dbd8b3d6522ae1f5eb2f6eb6d312