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Endocardial and epicardial myocardial perfusion determined by semi-quantitative and quantitative myocardial perfusion magnetic resonance
- Source :
- The International Journal of Cardiovascular Imaging. 28:1499-1511
- Publication Year :
- 2011
- Publisher :
- Springer Science and Business Media LLC, 2011.
-
Abstract
- This study aims to quantify subendocardial and subepicardial myocardial blood flow (MBF) from dynamic contrast-enhanced MRI and to compare semi-quantitative and quantitative analysis methods. 17 healthy volunteers (9 males, mean age 34 ± 8) were scanned during adenosine stress and at rest. A “semi-quantitative” myocardial perfusion index (MPI) was calculated based on maximal upslopes of signal intensity-time profiles for a mid-ventricular myocardial slice. In addition, absolute MBF (ml/g/min) was estimated using Fermi-constrained deconvolution. On semi-quantitative analysis, the ratio of subendocardial to subepicardial MPI was 0.98 ± 0.1 at stress and 1.16 ± 0.09 at rest, P < 0.0001. The MPRI (i.e. the ratio of stress over rest MPI) for the subendocardium was 1.54 ± 0.3 versus 1.81 ± 0.35 for the subepicardium, P = 0.03. For quantitative analysis, the ratio of subendocardial to subepicardial MBF was 0.91 ± 0.11 at stress versus 1.17 ± 0.16 at rest, P < 0.0001. The subendocardial MBF reserve was also lower than in the subepicardium (2.6 ± 0.75 vs. 3.32 ± 0.93, P = 0.027). In conclusion, semi-quantitative and quantitative analysis of dynamic contrast-enhanced MRI shows higher subendocardial blood flow at rest and reduced subendocardial perfusion reserve compared to the subepicardium.
- Subjects :
- Adult
Gadolinium DTPA
Male
medicine.medical_specialty
Adenosine
Time Factors
Vasodilator Agents
Contrast Media
Magnetic Resonance Imaging, Cine
Hemodynamics
Ventricular Function, Left
Hyperaemia
Coronary circulation
Predictive Value of Tests
Reference Values
Coronary Circulation
Internal medicine
medicine
Humans
Radiology, Nuclear Medicine and imaging
Endocardium
Cardiac imaging
Chi-Square Distribution
business.industry
Myocardial Perfusion Imaging
Blood flow
medicine.anatomical_structure
Regional Blood Flow
Dynamic contrast-enhanced MRI
Cardiology
Regression Analysis
Female
medicine.symptom
Cardiology and Cardiovascular Medicine
Nuclear medicine
business
Pericardium
Perfusion
Subjects
Details
- ISSN :
- 15730743 and 15695794
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- The International Journal of Cardiovascular Imaging
- Accession number :
- edsair.doi.dedup.....8e0880eb2f5a932c63345b5ec97e5582