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Mutual regulation and targeting of multidrug resistance and cancer stem phenotype
- Source :
- MedChemComm
- Publication Year :
- 2016
- Publisher :
- Royal Society of Chemistry (RSC), 2016.
-
Abstract
- Cancer-initiating cells referred to as cancer stem cells (CSCs) retain the essential property of self-renewal and protection. The protective mechanisms enable tumour regrowth even after the application of chemotherapy that was believed to be successful. Among the protective mechanisms of CSCs, the overexpression of ATP binding cassette (ABC) membrane transporters is highly important. ABC transporters involved in the development of cancer multidrug resistance (MDR) such as P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) are considered as particular features of CSCs. They provide a shield for CSCs and protect them from the adverse effects of chemotherapeutics. Hence, combating MDR would be one of the strategies for the elimination of CSCs. In order to investigate this phenomenon many model systems comprising MDR cancer cells have been established. Some of them were developed by a selection process through exposure to various anticancer drugs, others by transfection of genes for ABC transporters, while some were obtained by sorting the side population considered to possess stemness and resistant phenotypes. Herein we review the potential of cancer MDR models for studying CSCs because gaining a better insight into the mechanisms of CSC resistance to chemotherapy may lead to the discovery of new therapeutic targets and the development of better anticancer strategies.
- Subjects :
- 0301 basic medicine
Abcg2
Pharmaceutical Science
ATP-binding cassette transporter
Pharmacology
Biochemistry
03 medical and health sciences
0302 clinical medicine
Side population
Cancer stem cell
Drug Discovery
medicine
biology
Organic Chemistry
Cancer
Transfection
medicine.disease
3. Good health
Multiple drug resistance
030104 developmental biology
030220 oncology & carcinogenesis
Cancer cell
biology.protein
Cancer research
Molecular Medicine
Subjects
Details
- ISSN :
- 20402511 and 20402503
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- MedChemComm
- Accession number :
- edsair.doi.dedup.....8e3442d854e4201b5a8b3664d642b67f