Catalytic Enantioselective Oxa-Hetero-Diels-Alder Reactions of Enones with Aryl Trifluoromethyl Ketones: Synthesis of Tetrahydropyranones

Diastereo- and enantioselective oxa-hetero-Diels-Alder reactions of enones with aryl trifluoromethyl ketones that afford tetrahydropyranone derivatives catalyzed by an amine-based catalyst system are reported. The major diastereomers of the tetrahydropyranone products obtained in these reactions had the relative stereochemistry different from that of the previously synthesized tetrahydropyranone derivatives.