Additional file 7 of Reliable assessment of telomere maintenance mechanisms in neuroblastoma

Additional file 7: Figure S4. Detection of telomeric reads and calculation of telomere content on WGS data. (A) Number of detected telomeric reads, i.e., reads containing at least four t-type repeats, in tumor and normal WGS data in relation to the mean read depth. Pearson correlation displayed for normal controls only. (B) Normalized telomere content calculated from single tumor WGS data, dependent on telomere maintenance subgroups. Mean telomere content: TMM[-] 67.43, ALT[+] 339.33, TEL[+] 54.19. Kruskal-Wallis test and Dunn’s multiple comparison test, n=61, ambiguous cases were excluded from statistical analysis. Whiskers are limited to 1.5x interquartile range. (C) Correlation analysis of telomere content calculated from tumor/normal ratios and the respective single tumor samples.