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The effect of uptake inhibition on dopamine release from the nucleus accumbens of rats during self- or forced stimulation of the medial forebrain bundle: A microdialysis study

Authors :
Toshiharu Nagatsu
Daiichiro Nakahara
Norio Ozaki
Vimal Kapoor
Source :
Neuroscience Letters. 104:136-140
Publication Year :
1989
Publisher :
Elsevier BV, 1989.

Abstract

Changes in dopamine (DA) release were measured in microdialysis samples taken from the nucleus accumbens (NAC) of rats pretreated with the DA uptake inhibitor, nomifensine (1 mg/kg, i.p.) during self- or forced stimulation of the medial forebrain bundle (MFB). Self-stimulation of the MFB in nomifensine-pretreated rats caused an increased release of DA in the NAC. In the same rats, similar increases in DA release were also found during forced stimulation, that is, during MFB stimulation in the absence of lever-pressing, but at current and rate parameters identical to those recorded in the previous self-stimulation session. The results indicate that self-stimulation of the MFB activates the mesolimbic DA system; similar neurochemical changes observed during self- and forced stimulation of the MFB suggest that the operant lever-pressing behavior itself did not influence DA release in the NAC.

Details

ISSN :
03043940
Volume :
104
Database :
OpenAIRE
Journal :
Neuroscience Letters
Accession number :
edsair.doi.dedup.....8e8c06af279d118d553bee31b8c173a1
Full Text :
https://doi.org/10.1016/0304-3940(89)90343-1