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Roles of Two Small Leucine-Rich Proteoglycans Decorin and Biglycan in Pregnancy and Pregnancy-Associated Diseases

Authors :
Peeyush K. Lala
Chidambra Halari
Michael Zheng
Source :
International Journal of Molecular Sciences, Vol 22, Iss 10584, p 10584 (2021), Paediatrics Publications, International Journal of Molecular Sciences
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

Two small leucine-rich proteoglycans (SLRP), decorin and biglycan, play important roles in structural–functional integrity of the placenta and fetal membranes, and their alterations can result in several pregnancy-associated diseases. In this review, we briefly discuss normal placental structure and functions, define and classify SLRPs, and then focus on two SLRPs, decorin (DCN) and biglycan (BGN). We discuss the consequences of deletions/mutations of DCN and BGN. We then summarize DCN and BGN expression in the pregnant uterus, myometrium, decidua, placenta, and fetal membranes. Actions of these SLRPs as ligands are then discussed in the context of multiple binding partners in the extracellular matrix and cell surface (receptors), as well as their alterations in pathological pregnancies, such as preeclampsia, fetal growth restriction, and preterm premature rupture of membranes. Lastly, we raise some unanswered questions as food for thought.

Details

Language :
English
ISSN :
16616596 and 14220067
Volume :
22
Issue :
10584
Database :
OpenAIRE
Journal :
International Journal of Molecular Sciences
Accession number :
edsair.doi.dedup.....8e8cd9970acb1115b4f2e680c57476b3