Back to Search
Start Over
Roles of Two Small Leucine-Rich Proteoglycans Decorin and Biglycan in Pregnancy and Pregnancy-Associated Diseases
- Source :
- International Journal of Molecular Sciences, Vol 22, Iss 10584, p 10584 (2021), Paediatrics Publications, International Journal of Molecular Sciences
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Two small leucine-rich proteoglycans (SLRP), decorin and biglycan, play important roles in structural–functional integrity of the placenta and fetal membranes, and their alterations can result in several pregnancy-associated diseases. In this review, we briefly discuss normal placental structure and functions, define and classify SLRPs, and then focus on two SLRPs, decorin (DCN) and biglycan (BGN). We discuss the consequences of deletions/mutations of DCN and BGN. We then summarize DCN and BGN expression in the pregnant uterus, myometrium, decidua, placenta, and fetal membranes. Actions of these SLRPs as ligands are then discussed in the context of multiple binding partners in the extracellular matrix and cell surface (receptors), as well as their alterations in pathological pregnancies, such as preeclampsia, fetal growth restriction, and preterm premature rupture of membranes. Lastly, we raise some unanswered questions as food for thought.
- Subjects :
- Decorin
Placenta
Review
fetal growth restriction
Extracellular matrix
Pre-Eclampsia
trophoblast invasion
Pregnancy
Biglycan
Tropho-blast
Leucine-rich proteoglycans
Premature labor
Ehlers–Danlos syndrome (EDS)
Biology (General)
Spectroscopy
reproductive and urinary physiology
decorin
Fetal Growth Retardation
Decidua
Fetal growth restriction
Premature preterm rupture of membranes (PPROM)
General Medicine
Computer Science Applications
Cell biology
Trophoblast invasion
Chemistry
medicine.anatomical_structure
embryonic structures
Female
pregnancy
decidua
premature labor
placenta
QH301-705.5
premature preterm rupture of membranes (PPROM)
Context (language use)
Biology
leucine-rich proteoglycans
Catalysis
preeclampsia
Inorganic Chemistry
medicine
Animals
Humans
Physical and Theoretical Chemistry
Molecular Biology
QD1-999
Organic Chemistry
Trophoblast
medicine.disease
Preeclampsia
biglycan
trophoblast
carbohydrates (lipids)
Gene Expression Regulation
Mutation
Premature rupture of membranes
Subjects
Details
- Language :
- English
- ISSN :
- 16616596 and 14220067
- Volume :
- 22
- Issue :
- 10584
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....8e8cd9970acb1115b4f2e680c57476b3