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Functional hypothalamic and drug-induced amenorrhea: an overview
- Publication Year :
- 2019
-
Abstract
- Functional hypothalamic amenorrhea (FHA) is a form of chronic anovulation not due to identifiable organic causes and with adverse health consequences. The identification of women with this disorder or the precocious identification of women at risk is based on the knowledge of lifestyle risk factors or behaviors such as stress, weight loss, and excessive physical exercise that are known to negatively impact gonadal axis activity. In this overview, we described the most common forms of FHA, in particular stress-induced amenorrhea and overtraining-induced amenorrhea. In addition, although its mechanisms can differ from those involved in FHA, we reviewed the available literature on drug-induced amenorrhea, highlighting the clear connection between this condition and psychoactive drugs such as antipsychotics, antidepressants and anti-epilectics thus raising concern about the role that the abuse of substances such as opioids or alcohol can possibly have on the growing unexplained infertility of the female population.
- Subjects :
- Drug
endocrine system
Endocrinology, Diabetes and Metabolism
media_common.quotation_subject
Hypoestrogenism
Physiology
030209 endocrinology & metabolism
Hypothalamic amenorrhea
NO
Anovulation
03 medical and health sciences
0302 clinical medicine
Endocrinology
Weight loss
medicine
Alcohol, Drug-induced amenorrhea, Functional amenorrhea, Hypoestrogenism, Hypothalamic amenorrhea, Opiates
Humans
Amenorrhea
Drug-induced amenorrhea
media_common
Female population
Unexplained infertility
Psychotropic Drugs
business.industry
Functional amenorrhea
medicine.disease
Prognosis
Opiates
030220 oncology & carcinogenesis
Female
medicine.symptom
business
Alcohol
Hypothalamic Diseases
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....8ea8caaf6eaa06ba617e0f33eac242b1