Back to Search
Start Over
Effects of an Intermittent Grape-Seed Proanthocyanidin (GSPE) Treatment on a Cafeteria Diet Obesogenic Challenge in Rats
- Source :
- Nutrients, Nutrients, Vol 10, Iss 3, p 315 (2018), Nutrients; Volume 10; Issue 3; Pages: 315
- Publication Year :
- 2018
- Publisher :
- MDPI, 2018.
-
Abstract
- Obesity is highly associated with the pathologies included in the concept of the Metabolic Syndrome. Grape-seed proanthocyanins (GSPE) have showed very positive effects against all these metabolic disruptions; however, there is, as yet, no consensus about their effectiveness against an obesogenic challenge, such as a cafeteria diet. We determined the effectiveness of a dose of 500 mg GSPE/kg b.w. (body weight) against the obesogenic effects of a 17-week cafeteria diet, administered as a sub-chronic treatment, 10–15 days before, intermittently and at the end of the diet, in Wistar rats. Body weight, adiposity, indirect calorimetry and plasma parameters were analyzed. GSPE pre-treatment showed a long-lasting effect on body weight and adiposity that was maintained for seven weeks after the last dose. A corrective treatment was administered for the last two weeks of the cafeteria diet intervention; however, it did not effectively correct any of the parameters assessed. The most effective treatment was an intermittent GSPE dosage, administered every second week during the cafeteria diet. This limited body weight gain, adiposity and most lipotoxic effects. Our results support the administration of this GSPE dose, keeping an intermittent interval between dosages longer than every second week, to improve obesogenic disruptions produced by a cafeteria diet.
- Subjects :
- 0301 basic medicine
Blood Glucose
medicine.medical_treatment
Physiology
Fatty Acids, Nonesterified
Antioxidants
Insulin
rat
Adiposity
Nutrition and Dietetics
biology
dose
Grape seed extract
Body Composition
Female
medicine.symptom
lcsh:Nutrition. Foods and food supply
food.ingredient
Dose
cafeteria-diet
Cafeteria
lcsh:TX341-641
Article
metabolic syndrome
03 medical and health sciences
Insulin resistance
food
medicine
Animals
Proanthocyanidins
Obesity
Rats, Wistar
Triglycerides
030109 nutrition & dietetics
Dose-Response Relationship, Drug
Grape Seed Extract
business.industry
Tumor Necrosis Factor-alpha
Body Weight
proanthocyanidins
Calorimetry, Indirect
medicine.disease
biology.organism_classification
Diet
Rats
Disease Models, Animal
Metabolic syndrome
Insulin Resistance
business
Weight gain
Food Science
Subjects
Details
- Language :
- English
- ISSN :
- 20726643
- Volume :
- 10
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Nutrients
- Accession number :
- edsair.doi.dedup.....8eaaa1b2ac9481523b7a25116313ccf3