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Rutin mitigates hepatic fibrogenesis and inflammation through targeting TLR4 and P2X7 receptor signaling pathway in vitro and in vivo
- Source :
- Journal of Functional Foods, Vol 64, Iss, Pp 103700-(2020)
- Publication Year :
- 2020
- Publisher :
- Elsevier, 2020.
-
Abstract
- Rutin is a flavonol glycoside widely existing in plants, used as food antioxidant and nutritional enhancer. Rutin has vitamin P-like effect and anti-inflammatory effect. This study aims to investigate the effects and potential mechanisms of rutin against hepatic fibrosis in vivo and in vitro. The present study found that rutin significantly decreased fibrosis markers, and TLR4, IRAK4, P2X7r/NLRP3 signaling pathway in activated HSCs, as well as functioning as TLR4 inhibitor. In primary hepatocytes, rutin also inhibited TLR4-IRAK-P2X7r signaling pathway underlying TGF-β stimulation. In TAA-induced mice, rutin could attenuate the histopathological changes, fibrosis markers, and inflammatory factor. Rutin also suppressed TLRs, IL-1 receptor associated kinase, P2X7r, and NLRP3 expressions. Activation of TLRs/P2X7r signaling is required for HSCs activation, contributing to hepatic fibrosis in mice. Rutin exhibited a protective effect against hepatic fibrosis at least partly through suppressing TLR4 and P2X7r signaling.
- Subjects :
- 0301 basic medicine
Rutin
P2X7r
Medicine (miscellaneous)
Inflammation
Pharmacology
03 medical and health sciences
chemistry.chemical_compound
0404 agricultural biotechnology
Fibrosis
In vivo
medicine
TX341-641
TLRs
030109 nutrition & dietetics
Nutrition and Dietetics
Nutrition. Foods and food supply
04 agricultural and veterinary sciences
medicine.disease
IRAK4
040401 food science
chemistry
TLR4
medicine.symptom
Signal transduction
Hepatic fibrosis
Food Science
Subjects
Details
- Language :
- English
- ISSN :
- 17564646
- Volume :
- 64
- Database :
- OpenAIRE
- Journal :
- Journal of Functional Foods
- Accession number :
- edsair.doi.dedup.....8ecd31769071aa26342ab59abad26869