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ROS-responsive EPO nanoparticles ameliorate ionizing radiation-induced hematopoietic injury
- Source :
- Biomaterials Science. 9:6474-6485
- Publication Year :
- 2021
- Publisher :
- Royal Society of Chemistry (RSC), 2021.
-
Abstract
- Stimulus-responsive polymer materials have attracted much attention as drug carriers because of the ability to deliver drugs to the active site. Reactive oxygen species (ROS) play crucial roles in cellular signaling and regulation of oxygen homeostasis. However, ROS are present in abnormally high levels in many pathological environments. Based on the above points, three-arm poly(lactic-co-glycolic acid)-PO-poly(ethylene glycol) (3s-PLGA-PO-PEG or simply PP) was synthesized by using peroxalate esters (PO) as hydrogen peroxide-responsive linkages. PP was used to deliver promote hematopoietic recovery drugs erythropoietin (EPO) and EPO nanoparticles (EPO NPs) were prepared. We established a hematopoietic system injury model by ionizing radiation (IR) and unexpectedly found the good therapeutic effect of blank PP. Moreover, the administration of EPO NPs obviously decreased IR-induced ROS in bone marrow cells (BMCs) and reconstituted hematopoietic stem cells in BMCs. This study reveals a novel ROS-responsive polymer material that could be employed to remove excess ROS in the lesion and promote the efficacy of drug therapy.
- Subjects :
- chemistry.chemical_classification
Drug Carriers
Cell signaling
Reactive oxygen species
Biomedical Engineering
Haematopoiesis
medicine.anatomical_structure
chemistry
Erythropoietin
Radiation, Ionizing
Oxygen homeostasis
medicine
Cancer research
Nanoparticles
General Materials Science
Bone marrow
Stem cell
Reactive Oxygen Species
Drug carrier
medicine.drug
Subjects
Details
- ISSN :
- 20474849 and 20474830
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Biomaterials Science
- Accession number :
- edsair.doi.dedup.....8eee406e1074ece7fbe10c95abf03cae