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Muscarinic receptor subtypes in the rat prostate gland
- Source :
- European journal of pharmacology. 343(2-3)
- Publication Year :
- 1998
-
Abstract
- Muscarinic receptor subtypes mediating carbachol-induced contractions of the rat prostatic smooth muscle were determined. The rank order of potency of muscarinic receptor antagonists in blocking the effects of carbachol was (mean pKB estimates in parentheses): atropine (8.90) >> para-fluorohexahydrosiladifenidol (7.75) > or = hexahydrosiladifenidol (7.62) > methoctramine (6.89) > or = pirenzepine (6.68) > or = himbacine (6.67). The specific binding of [3H]quinuclidinyl benzilate to the rat prostatic homogenates was competitively inhibited by (mean pKi values in parentheses): atropine (8.89) >> hexahydrosiladifenidol (7.86) > para-fluorohexahydrosiladifenidol (7.28) > or = himbacine (7.22) > pirenzepine (6.63) > or = methoctramine (6.38). These profiles, whilst different, indicate the probable involvement of muscarinic M3 receptors in the carbachol-induced contraction.
- Subjects :
- Male
medicine.medical_specialty
Carbachol
Cholinergic Agents
In Vitro Techniques
Binding, Competitive
Rats, Sprague-Dawley
chemistry.chemical_compound
Radioligand Assay
Internal medicine
Muscarinic acetylcholine receptor
medicine
Methoctramine
Animals
Pharmacology
Prostate
Muscarinic acetylcholine receptor M3
Muscarinic acetylcholine receptor M1
Pirenzepine
Receptors, Muscarinic
Quinuclidinyl Benzilate
Rats
Endocrinology
chemistry
Himbacine
medicine.drug
Subjects
Details
- ISSN :
- 00142999
- Volume :
- 343
- Issue :
- 2-3
- Database :
- OpenAIRE
- Journal :
- European journal of pharmacology
- Accession number :
- edsair.doi.dedup.....8f01f30a1b22a6c39ff4bd084643378b