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Dynamic, Transient, and Robust Increase in the Innervation of the Inflamed Mucosa in Inflammatory Bowel Diseases
- Source :
- Cells, Volume 10, Issue 9, Cells, Vol 10, Iss 2253, p 2253 (2021)
- Publication Year :
- 2021
-
Abstract
- Inflammatory bowel diseases (IBD) are characterized by chronic dysregulation of immune homeostasis, epithelial demise, immune cell activation, and microbial translocation. Each of these processes leads to proinflammatory changes via the release of cytokines, damage-associated molecular patterns (DAMPs), and pathogen-associated molecular patterns (PAMPs), respectively. The impact of these noxious agents on the survival and function of the enteric nervous system (ENS) is poorly understood. Here, we show that in contrast to an expected decrease, experimental as well as clinical colitis causes an increase in the transcript levels of enteric neuronal and glial genes. Immunostaining revealed an elevated neuronal innervation of the inflamed regions of the gut mucosa. The increase was seen in models with overt damage to epithelial cells and models of T cell-induced colitis. Transcriptomic data from treatment naïve pediatric IBD patients also confirmed the increase in the neuroglial genes and were replicated on an independent adult IBD dataset. This induction in the neuroglial genes was transient as levels returned to normal upon the induction of remission in both mouse models as well as colitis patients. Our data highlight the dynamic and robust nature of the enteric nervous system in colitis and open novel questions on its regulation.
- Subjects :
- Crohn’s disease
QH301-705.5
Enteric Nervous System
Article
Proinflammatory cytokine
Transcriptome
Mice
medicine
Animals
ddc:610
Biology (General)
Colitis
Intestinal Mucosa
ulcerative colitis
Neurons
Crohn's disease
business.industry
Neurogenesis
General Medicine
medicine.disease
Inflammatory Bowel Diseases
Ulcerative colitis
neurogenesis
Immunology
Enteric nervous system
business
Immunostaining
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Cells, Volume 10, Issue 9, Cells, Vol 10, Iss 2253, p 2253 (2021)
- Accession number :
- edsair.doi.dedup.....8f0b6467b04c789ac9c8fd61e2c0203e