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Femoral artery plaque characteristics, lower extremity collaterals, and mobility loss in peripheral artery disease
- Source :
- Vascular medicine (London, England), vol 22, iss 6
- Publication Year :
- 2017
- Publisher :
- SAGE Publications, 2017.
-
Abstract
- Little is known about the prognostic significance of specific characteristics of magnetic resonance imaging (MRI) measured plaque in the superficial femoral artery (SFA). Associations of MRI-measured plaque quantity, lumen area, and plaque composition in the SFA with subsequent mobility loss were studied in people with lower extremity peripheral artery disease (PAD). Participants with an ankle–brachial index (ABI) < 1.00 were identified from Chicago medical centers and underwent direct visualization of atherosclerotic plaque in the SFA using MRI. Participants were followed annually for up to 4 years. Mobility loss was defined as becoming unable to walk up and down a flight of stairs or walk one-quarter of a mile without assistance among participants without mobility impairment at baseline. Analyses adjusted for age, sex, race, comorbidities, ABI, physical activity, and other confounders. Of 308 PAD participants without baseline mobility impairment, 100 (32.5%) developed mobility loss during follow-up. Compared to the lowest mean plaque area tertile at baseline, participants in the highest (worst) plaque area tertile had a higher rate of mobility loss (hazard ratio (HR) = 2.08, 95% confidence interval (CI) = 1.14–3.79, p = 0.018). Compared to the highest mean lumen area tertile, the smallest (worst) mean lumen area tertile was associated with greater mobility loss (HR = 2.18, 95% CI = 1.20–3.96, p = 0.011). Neither lipid rich necrotic core nor calcium in the SFA were associated with mobility loss. In conclusion, greater plaque quantity and smaller lumen area in the proximal SFA, but not lipid rich necrotic core or calcium, were associated with higher mobility loss in people with PAD.
- Subjects :
- Male
Time Factors
lipid rich necrotic core
Femoral artery
atherosclerotic plaque
030204 cardiovascular system & hematology
Cardiovascular
0302 clinical medicine
Risk Factors
80 and over
Longitudinal Studies
030212 general & internal medicine
Plaque
Atherosclerotic
Aged, 80 and over
medicine.diagnostic_test
Confounding
Hazard ratio
intermittent claudication
Lipids
Plaque, Atherosclerotic
mobility
Femoral Artery
Cardiology
Biomedical Imaging
Female
medicine.symptom
Cardiology and Cardiovascular Medicine
medicine.medical_specialty
Clinical Sciences
Collateral Circulation
Lumen (anatomy)
Walk Test
peripheral artery disease
Article
Necrosis
Peripheral Arterial Disease
03 medical and health sciences
Predictive Value of Tests
Clinical Research
medicine.artery
Internal medicine
medicine
Humans
Ankle Brachial Index
Peripheral artery disease (PAD)
Mobility Limitation
Vascular Calcification
Aged
Chicago
business.industry
Magnetic resonance imaging
medicine.disease
Dependent Ambulation
Intermittent claudication
Confidence interval
Cardiovascular System & Hematology
Regional Blood Flow
business
Magnetic Resonance Angiography
Subjects
Details
- ISSN :
- 14770377 and 1358863X
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Vascular Medicine
- Accession number :
- edsair.doi.dedup.....8f127deff77f0b55d358fda7a76590ea