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Moderate intake of docosahexaenoic acid raises plasma and platelet vitamin E levels in cystic fibrosis patients
- Source :
- Prostaglandins, Leukotrienes and Essential Fatty Acids, Prostaglandins, Leukotrienes and Essential Fatty Acids, Elsevier, 2016, 115, pp.41-47. ⟨10.1016/j.plefa.2016.10.008⟩
- Publication Year :
- 2016
- Publisher :
- HAL CCSD, 2016.
-
Abstract
- International audience; Patients with cystic fibrosis have increased oxidative stress and impaired antioxidant systems. Moderate intake of docosahexaenoic acid (DHA) may favor the lowering of oxidative stress. In this randomized, double-blind, cross-over study, DHA or placebo capsules, were given daily to 10 patients, 5 mg/kg for 2 weeks then 10 mg/kg DHA for the next 2 weeks (or placebo). After 9 weeks of wash-out, patients took placebo or DHA capsules. Biomarkers of lipid peroxidation and vitamin E were measured at baseline, and after 2 and 4 weeks of treatment in each phase. The proportions of DHA increased both in plasma and platelet lipids after DHA supplementations. The lipid peroxidation markers did not significantly decrease, in spite of a trend, after the first and/or the second dose of DHA but plasma and platelet vitamin E amounts increased significantly after DHA supplementation. Our findings reinforce the antioxidant potential of moderate DHA intake in subjects displaying increased oxidative stress.
- Subjects :
- Adult
Blood Platelets
Male
0301 basic medicine
medicine.medical_specialty
Antioxidant
Adolescent
Cystic Fibrosis
Docosahexaenoic Acids
genetic structures
medicine.medical_treatment
Clinical Biochemistry
Placebo
medicine.disease_cause
Cystic fibrosis
antioxidant status
Drug Administration Schedule
platelet lipid
Lipid peroxidation
Young Adult
03 medical and health sciences
chemistry.chemical_compound
Double-Blind Method
Internal medicine
medicine
Humans
Vitamin E
oxidative stress
Child
plasma
Cross-Over Studies
business.industry
food and beverages
Cell Biology
docosahexaenoic acid
medicine.disease
3. Good health
Thromboxane B2
[SDV.AEN] Life Sciences [q-bio]/Food and Nutrition
030104 developmental biology
Endocrinology
chemistry
Docosahexaenoic acid
lipids (amino acids, peptides, and proteins)
Lipid Peroxidation
business
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Oxidative stress
Subjects
Details
- Language :
- English
- ISSN :
- 09523278
- Database :
- OpenAIRE
- Journal :
- Prostaglandins, Leukotrienes and Essential Fatty Acids, Prostaglandins, Leukotrienes and Essential Fatty Acids, Elsevier, 2016, 115, pp.41-47. ⟨10.1016/j.plefa.2016.10.008⟩
- Accession number :
- edsair.doi.dedup.....8f18633cd621d71f963bc2783319daae