Sitagliptin improves glycaemic excursion after a meal or after an oral glucose load in <scp>J</scp> apanese subjects with impaired glucose tolerance

Aims To evaluate the efficacy and tolerability of sitagliptin in subjects with impaired glucose tolerance (IGT). Methods In a double-blind, parallel-group study, 242 Japanese subjects with IGT, determined by a 75-g oral glucose tolerance test (OGTT) at week −1, were randomized (1 : 1 : 1) to placebo (n = 83), sitagliptin 25 mg (n = 82) or 50 mg (n = 77) once daily for 8 weeks. Glycaemic variables were assessed using another OGTT at week 7 and meal tolerance tests (MTTs) at weeks 0 and 8. Primary and secondary endpoints were percent change from baseline in glucose total area under the curve 0–2 h (AUC0–2 h) during the MTT and OGTT, respectively. Results Least squares mean percent change from baseline in glucose AUC0–2 h during the MTT were −2.4, −9.5 and −11.5%, and during the OGTT were −3.7, −21.4 and −20.1% with placebo, sitagliptin 25 mg once daily, and 50 mg once daily, respectively (p