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The developing brain structural and functional connectome fingerprint

Authors :
Lucilio Cordero-Grande
Grainne M. McAlonan
Tomoki Arichi
Emer Hughes
Daniel Rueckert
Joseph V. Hajnal
Eugene P. Duff
Dafnis Batalle
Jana Hutter
Sean P. Fitzgibbon
Jacques-Donald Tournier
Ralica Dimitrova
Anthony N. Price
Alexander D. Edwards
Judit Ciarrusta
Daan Christiaens
Commission of the European Communities
Publication Year :
2022
Publisher :
Elsevier, 2022.

Abstract

In the mature brain, structural and functional 'fingerprints' of brain connectivity can be used to identify the uniqueness of an individual. However, whether the characteristics that make a given brain distinguishable from others already exist at birth remains unknown. Here, we used neuroimaging data from the developing Human Connectome Project (dHCP) of preterm born neonates who were scanned twice during the perinatal period to assess the developing brain fingerprint. We found that 62% of the participants could be identified based on the congruence of the later structural connectome to the initial connectivity matrix derived from the earlier timepoint. In contrast, similarity between functional connectomes of the same subject at different time points was low. Only 10% of the participants showed greater self-similarity in comparison to self-to-other-similarity for the functional connectome. These results suggest that structural connectivity is more stable in early life and can represent a potential connectome fingerprint of the individual: a relatively stable structural connectome appears to support a changing functional connectome at a time when neonates must rapidly acquire new skills to adapt to their new environment. ispartof: DEVELOPMENTAL COGNITIVE NEUROSCIENCE vol:55 ispartof: location:Netherlands status: published

Details

Language :
English
Database :
OpenAIRE
Accession number :
edsair.doi.dedup.....8f578b82f2fd83e44ab29a5f793021f1