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Relationship between nitroglycerine-induced vasodilation and clinical severity of peripheral artery disease
- Source :
- Atherosclerosis. 235(1)
- Publication Year :
- 2014
-
Abstract
- Nitroglycerine-induced vasodilation is usually used as a control test for flow-mediated vasodilation (FMD). However, nitroglycerine-induced vasodilation per se has also been reported to be impaired in patients with atherosclerosis. The purpose of this study was to determine the relationship between nitroglycerine-induced vasodilation and the clinical severity of peripheral artery disease (PAD).We measured nitroglycerine-induced vasodilation and FMD in 144 subjects (mean age: 63.8 ± 15.1 years), including 32 PAD patients with critical limb ischemia (CLI group), 28 PAD patients without CLI (non-CLI group), 60 age- and sex-matched patients without established cardiovascular disease (at-risk group), and 24 healthy subjects (healthy group). Nitroglycerine-induced vasodilation was significantly impaired in the CLI group compared to that in the other three groups (healthy group, 16.0 ± 5.3%; at-risk group, 12.9 ± 3.8%; non-CLI group, 10.3 ± 5.1%; CLI group, 6.7 ± 3.9%; P0.05, respectively). Even after multivariate adjustment, the differences remained significant. On the other hand, FMD was significantly impaired in the at-risk, non-CLI, and CLI group compared with that in the healthy group (healthy group, 7.1 ± 2.9%; at-risk group, 3.4 ± 2.3%; non-CLI group, 3.5 ± 2.7%; CLI group, 3.0 ± 2.8%; P0.001, respectively), but the differences among the at-risk, non-CLI, and CLI groups were not significant. Multivariate analysis revealed that nitroglycerine-induced vasodilation (odds ratio: 0.77, 95% confidence interval [CI]: 0.61-0.97) and diabetes mellitus (odds ratio: 8.75, 95% CI: 1.74-44.2) were independent variables for CLI in PAD patients.There was no significant difference in FMD between PAD patients with and those without CLI, but nitroglycerine-induced vasodilation was significantly smaller in PAD patients with CLI compared with those without CLI.
- Subjects :
- Adult
Male
Brachial Artery
Arterial disease
Vasodilator Agents
Vasodilation
Disease
Nitroglycerin
Peripheral Arterial Disease
Young Adult
Ischemia
Medicine
Humans
In patient
Clinical severity
cardiovascular diseases
Aged
business.industry
Significant difference
Critical limb ischemia
Middle Aged
Atherosclerosis
body regions
Anesthesia
Case-Control Studies
cardiovascular system
Female
Endothelium, Vascular
medicine.symptom
Cardiology and Cardiovascular Medicine
business
circulatory and respiratory physiology
Flow-Mediated Vasodilation
Subjects
Details
- ISSN :
- 18791484
- Volume :
- 235
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Atherosclerosis
- Accession number :
- edsair.doi.dedup.....8f5f21ecbde37a02cb838f01c852182f